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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July 1994 Volume 1 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 1994 Volume 1 Issue 4

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Article

CYTOSOL AND SERUM CONCENTRATION OF CYTOKERATIN SUBUNIT-19 FRAGMENT (CYFRA-21-1) IN BREAST-CANCER

  • Authors:
    • T NARITA
    • H FUNAHASHI
    • T IMAI
    • H TAKAGI
    • R KANNAGI

  • View Affiliations / Copyright

    Affiliations: NAGOYA UNIV,SCH MED,DEPT SURG 2,SHOWA KU,NAGOYA,AICHI 466,JAPAN.
  • Pages: 747-750
    |
    Published online on: July 1, 1994
       https://doi.org/10.3892/or.1.4.747
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Abstract

Cytokeratin 19 is a subunit of cytokeratin intermediate filament. CYFRA 21-1 is a new tumor marker using monoclonal antibodies which recognize a fragment of cytokeratin 19. CYFRA 21-1 was measured in cytosol of breast cancer tissues or in sera of patients with breast cancer or benign breast diseases to study the significance of this protein as a tumor marker. The cytosol concentration of CYFRA 21-1 was elevated in cancerous tissue compared to that in adjacent noncancerous tissue, and correlated with the tumor stage or the estrogen receptor status. In the serum, the mean value and positive rate for CYFRA 21-1 (assuming 2.2 ng/ml as the cut-off value) were 0.61 ng/ml (0%) in benign breast diseases, 0.98 ng/ml (6.7%) in stage I/II primary breast cancer, 75.67 ng/ml (60.0%) in stage III/IV primary breast cancer, 45.28 ng/ml (60.0%) in recurrent breast cancer, and 0.64 ng/ml (2.6%) in those with no evidence of recurrence. From the above, we concluded that CYFRA 21-1 could be a tumor marker with high specificity in breast cancer.

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Copy and paste a formatted citation
Spandidos Publications style
NARITA T, FUNAHASHI H, IMAI T, TAKAGI H and KANNAGI R: CYTOSOL AND SERUM CONCENTRATION OF CYTOKERATIN SUBUNIT-19 FRAGMENT (CYFRA-21-1) IN BREAST-CANCER. Oncol Rep 1: 747-750, 1994.
APA
NARITA, T., FUNAHASHI, H., IMAI, T., TAKAGI, H., & KANNAGI, R. (1994). CYTOSOL AND SERUM CONCENTRATION OF CYTOKERATIN SUBUNIT-19 FRAGMENT (CYFRA-21-1) IN BREAST-CANCER. Oncology Reports, 1, 747-750. https://doi.org/10.3892/or.1.4.747
MLA
NARITA, T., FUNAHASHI, H., IMAI, T., TAKAGI, H., KANNAGI, R."CYTOSOL AND SERUM CONCENTRATION OF CYTOKERATIN SUBUNIT-19 FRAGMENT (CYFRA-21-1) IN BREAST-CANCER". Oncology Reports 1.4 (1994): 747-750.
Chicago
NARITA, T., FUNAHASHI, H., IMAI, T., TAKAGI, H., KANNAGI, R."CYTOSOL AND SERUM CONCENTRATION OF CYTOKERATIN SUBUNIT-19 FRAGMENT (CYFRA-21-1) IN BREAST-CANCER". Oncology Reports 1, no. 4 (1994): 747-750. https://doi.org/10.3892/or.1.4.747
Copy and paste a formatted citation
x
Spandidos Publications style
NARITA T, FUNAHASHI H, IMAI T, TAKAGI H and KANNAGI R: CYTOSOL AND SERUM CONCENTRATION OF CYTOKERATIN SUBUNIT-19 FRAGMENT (CYFRA-21-1) IN BREAST-CANCER. Oncol Rep 1: 747-750, 1994.
APA
NARITA, T., FUNAHASHI, H., IMAI, T., TAKAGI, H., & KANNAGI, R. (1994). CYTOSOL AND SERUM CONCENTRATION OF CYTOKERATIN SUBUNIT-19 FRAGMENT (CYFRA-21-1) IN BREAST-CANCER. Oncology Reports, 1, 747-750. https://doi.org/10.3892/or.1.4.747
MLA
NARITA, T., FUNAHASHI, H., IMAI, T., TAKAGI, H., KANNAGI, R."CYTOSOL AND SERUM CONCENTRATION OF CYTOKERATIN SUBUNIT-19 FRAGMENT (CYFRA-21-1) IN BREAST-CANCER". Oncology Reports 1.4 (1994): 747-750.
Chicago
NARITA, T., FUNAHASHI, H., IMAI, T., TAKAGI, H., KANNAGI, R."CYTOSOL AND SERUM CONCENTRATION OF CYTOKERATIN SUBUNIT-19 FRAGMENT (CYFRA-21-1) IN BREAST-CANCER". Oncology Reports 1, no. 4 (1994): 747-750. https://doi.org/10.3892/or.1.4.747
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