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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July 1994 Volume 1 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 1994 Volume 1 Issue 4

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DOUBLE ALTERNATE MODULATION OF HIGH-DOSE 5-FLUOROURACIL BY INTERFERON-ALPHA-2B AND PHOSPHONACETYL-L-ASPARTIC ACID IN PATIENTS WITH ADVANCED COLORECTAL-CANCER

  • Authors:
    • CJA PUNT
    • JTM BURGHOUTS
    • I KATEMAN
    • JJ CROLES
    • YL KAMM
    • DJT WAGENER

  • View Affiliations / Copyright

    Affiliations: BOSCH MEDICENTRUM,DEPT INTERNAL MED,SHERTOGENBOSCH,NETHERLANDS. STICHTING DOETINCHEMSE ZIEKENHUIZEN,DEPT INTERNAL MED,DOETINCHEM,NETHERLANDS.
  • Pages: 755-757
    |
    Published online on: July 1, 1994
       https://doi.org/10.3892/or.1.4.755
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Abstract

We conducted a multicenter phase II trial in patients with advanced colorectal cancer to investigate the antitumor efficacy of double alternate modulation of high-dose infusional 5-fluorouracil (5FU) (60 mg/kg/48 h = 2400 mg/m(2)/48 h) by interferon alpha-2b (IFN alpha) (10 MU/dose s.c. prior to and halfway 5FU, uneven cycles) and phosphonacetyl-L-aspartic acid (PALA) (250 mg/m(2) i.v. 24 h before 5FU, even cycles). Cycles were given weekly for 4 weeks and once every 2 weeks thereafter. Twenty one patients with progressive or symptomatic disease were treated ambulatory. Two patients (10%, 95% confidence interval 1-30%) achieved a partial response. Therefore, this schedule of double alternate modulation of 5FU is unlikely to be superior to single modulation of 5FU in patients with advanced colorectal cancer. Since no grade III/IV toxicity (WHO) occurred during 251 cycles, which is in contrast to our previous studies using the same 5FU schedule, it might be possible that alternate modulation allows more intense 5FU schedules compared to single or double modulation schedules.

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Copy and paste a formatted citation
Spandidos Publications style
PUNT C, BURGHOUTS J, KATEMAN I, CROLES J, KAMM Y and WAGENER D: DOUBLE ALTERNATE MODULATION OF HIGH-DOSE 5-FLUOROURACIL BY INTERFERON-ALPHA-2B AND PHOSPHONACETYL-L-ASPARTIC ACID IN PATIENTS WITH ADVANCED COLORECTAL-CANCER. Oncol Rep 1: 755-757, 1994.
APA
PUNT, C., BURGHOUTS, J., KATEMAN, I., CROLES, J., KAMM, Y., & WAGENER, D. (1994). DOUBLE ALTERNATE MODULATION OF HIGH-DOSE 5-FLUOROURACIL BY INTERFERON-ALPHA-2B AND PHOSPHONACETYL-L-ASPARTIC ACID IN PATIENTS WITH ADVANCED COLORECTAL-CANCER. Oncology Reports, 1, 755-757. https://doi.org/10.3892/or.1.4.755
MLA
PUNT, C., BURGHOUTS, J., KATEMAN, I., CROLES, J., KAMM, Y., WAGENER, D."DOUBLE ALTERNATE MODULATION OF HIGH-DOSE 5-FLUOROURACIL BY INTERFERON-ALPHA-2B AND PHOSPHONACETYL-L-ASPARTIC ACID IN PATIENTS WITH ADVANCED COLORECTAL-CANCER". Oncology Reports 1.4 (1994): 755-757.
Chicago
PUNT, C., BURGHOUTS, J., KATEMAN, I., CROLES, J., KAMM, Y., WAGENER, D."DOUBLE ALTERNATE MODULATION OF HIGH-DOSE 5-FLUOROURACIL BY INTERFERON-ALPHA-2B AND PHOSPHONACETYL-L-ASPARTIC ACID IN PATIENTS WITH ADVANCED COLORECTAL-CANCER". Oncology Reports 1, no. 4 (1994): 755-757. https://doi.org/10.3892/or.1.4.755
Copy and paste a formatted citation
x
Spandidos Publications style
PUNT C, BURGHOUTS J, KATEMAN I, CROLES J, KAMM Y and WAGENER D: DOUBLE ALTERNATE MODULATION OF HIGH-DOSE 5-FLUOROURACIL BY INTERFERON-ALPHA-2B AND PHOSPHONACETYL-L-ASPARTIC ACID IN PATIENTS WITH ADVANCED COLORECTAL-CANCER. Oncol Rep 1: 755-757, 1994.
APA
PUNT, C., BURGHOUTS, J., KATEMAN, I., CROLES, J., KAMM, Y., & WAGENER, D. (1994). DOUBLE ALTERNATE MODULATION OF HIGH-DOSE 5-FLUOROURACIL BY INTERFERON-ALPHA-2B AND PHOSPHONACETYL-L-ASPARTIC ACID IN PATIENTS WITH ADVANCED COLORECTAL-CANCER. Oncology Reports, 1, 755-757. https://doi.org/10.3892/or.1.4.755
MLA
PUNT, C., BURGHOUTS, J., KATEMAN, I., CROLES, J., KAMM, Y., WAGENER, D."DOUBLE ALTERNATE MODULATION OF HIGH-DOSE 5-FLUOROURACIL BY INTERFERON-ALPHA-2B AND PHOSPHONACETYL-L-ASPARTIC ACID IN PATIENTS WITH ADVANCED COLORECTAL-CANCER". Oncology Reports 1.4 (1994): 755-757.
Chicago
PUNT, C., BURGHOUTS, J., KATEMAN, I., CROLES, J., KAMM, Y., WAGENER, D."DOUBLE ALTERNATE MODULATION OF HIGH-DOSE 5-FLUOROURACIL BY INTERFERON-ALPHA-2B AND PHOSPHONACETYL-L-ASPARTIC ACID IN PATIENTS WITH ADVANCED COLORECTAL-CANCER". Oncology Reports 1, no. 4 (1994): 755-757. https://doi.org/10.3892/or.1.4.755
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