CEA AND CA-19.9 AS MARKERS OF COLORECTAL NEOPLASMS DURING CHEMOTHERAPEUTIC TREATMENT
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- Published online on: July 1, 1994 https://doi.org/10.3892/or.1.4.779
- Pages: 779-782
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Abstract
Carcinoembryonic antigen and CA 19.9 are markers of colorectal neoplasms, often related to tumor burden. Elevated pre-operative levels parallel disease extent and may foresee adverse prognosis. CEA and CA 19.9 may increase post-operatively, indicating tumor recurrence. Only limited data are available on the influence of chemotherapeutic treatments on these two markers, to detect chemotherapy-induced cytolysis. We measured CEA and CA 19.9 before and after a chemotherapy regimen of five days consisting of folinic acid and 5-fluorouracil in forty patients with colorectal cancer. No consistent fluctuation was detected, the examined tumor markers being related in a given patient only to tumor burden.