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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July 1994 Volume 1 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 1994 Volume 1 Issue 4

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Article

THE PROGNOSTIC-SIGNIFICANCE OF CATHEPSIN-D IN BREAST CARCINOMAS - AN IMMUNOHISTOCHEMICAL STUDY

  • Authors:
    • T HAERSLEV
    • GK JACOBSEN
    • K ZEDELER

  • View Affiliations / Copyright

    Affiliations: UNIV COPENHAGEN,DANISH BREAST CANC COOPERAT GRP,DK-2200 COPENHAGEN N,DENMARK.
  • Pages: 787-793
    |
    Published online on: July 1, 1994
       https://doi.org/10.3892/or.1.4.787
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Abstract

Cathepsin D, a lysosomal protease, was examined by immunohistochemistry in 481 breast carcinomas. The immunoreactivity for cathepsin D was registered in the tumour cells, in the surrounding stroma, and in the macrophages and correlated with clinicopathological parameters. In univariate analysis of survival data, less than 25% positive tumour cells, any positivity in the stroma, and moderate or strong positivity in the macrophages were poor prognostic parameters. In multivariate analysis, all three parameters were of independent prognostic significance; therefore a cathepsin D index was constructed. In multivariate analysis the cathepsin D index was also found to be of independent poor prognostic significance both in patients with and without lymph node metastases. Progesterone receptor status was an independent prognostic parameter in patients with lymph node metastases. From the present study we concluded that the cathepsin D index was a independent poor prognostic parameter.

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Copy and paste a formatted citation
Spandidos Publications style
HAERSLEV T, JACOBSEN G and ZEDELER K: THE PROGNOSTIC-SIGNIFICANCE OF CATHEPSIN-D IN BREAST CARCINOMAS - AN IMMUNOHISTOCHEMICAL STUDY. Oncol Rep 1: 787-793, 1994.
APA
HAERSLEV, T., JACOBSEN, G., & ZEDELER, K. (1994). THE PROGNOSTIC-SIGNIFICANCE OF CATHEPSIN-D IN BREAST CARCINOMAS - AN IMMUNOHISTOCHEMICAL STUDY. Oncology Reports, 1, 787-793. https://doi.org/10.3892/or.1.4.787
MLA
HAERSLEV, T., JACOBSEN, G., ZEDELER, K."THE PROGNOSTIC-SIGNIFICANCE OF CATHEPSIN-D IN BREAST CARCINOMAS - AN IMMUNOHISTOCHEMICAL STUDY". Oncology Reports 1.4 (1994): 787-793.
Chicago
HAERSLEV, T., JACOBSEN, G., ZEDELER, K."THE PROGNOSTIC-SIGNIFICANCE OF CATHEPSIN-D IN BREAST CARCINOMAS - AN IMMUNOHISTOCHEMICAL STUDY". Oncology Reports 1, no. 4 (1994): 787-793. https://doi.org/10.3892/or.1.4.787
Copy and paste a formatted citation
x
Spandidos Publications style
HAERSLEV T, JACOBSEN G and ZEDELER K: THE PROGNOSTIC-SIGNIFICANCE OF CATHEPSIN-D IN BREAST CARCINOMAS - AN IMMUNOHISTOCHEMICAL STUDY. Oncol Rep 1: 787-793, 1994.
APA
HAERSLEV, T., JACOBSEN, G., & ZEDELER, K. (1994). THE PROGNOSTIC-SIGNIFICANCE OF CATHEPSIN-D IN BREAST CARCINOMAS - AN IMMUNOHISTOCHEMICAL STUDY. Oncology Reports, 1, 787-793. https://doi.org/10.3892/or.1.4.787
MLA
HAERSLEV, T., JACOBSEN, G., ZEDELER, K."THE PROGNOSTIC-SIGNIFICANCE OF CATHEPSIN-D IN BREAST CARCINOMAS - AN IMMUNOHISTOCHEMICAL STUDY". Oncology Reports 1.4 (1994): 787-793.
Chicago
HAERSLEV, T., JACOBSEN, G., ZEDELER, K."THE PROGNOSTIC-SIGNIFICANCE OF CATHEPSIN-D IN BREAST CARCINOMAS - AN IMMUNOHISTOCHEMICAL STUDY". Oncology Reports 1, no. 4 (1994): 787-793. https://doi.org/10.3892/or.1.4.787
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