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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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September 1994 Volume 1 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 1994 Volume 1 Issue 5

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Article

ALTERATIONS OF THE IN-VIVO GROWTH-PATTERN OF XENOTRANSPLANTED HUMAN-MALIGNANT MELANOMAS AFTER SURAMIN TREATMENT IN NUDE-MICE

  • Authors:
    • ID BASSUKAS

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  • Pages: 981-986
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    Published online on: September 1, 1994
       https://doi.org/10.3892/or.1.5.981
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Abstract

The effect of suramin on the in vivo growth of 4 human malignant melanoma xenotransplantation lines in nude mice was studies. The drug (multiple i.p. injections of 80 mg/kg) was well tolerated by the animals, however, no tumor regressions were seen. All 8 different sets of tumor growth data (4 treated and 4 control groups of 8 tumor-bearing animals each) fitted well to the Gompertz difference equation, which enables to precisely analyse the pattern of tumor growth. The results show that suramin treatment leads to a statistically significant inhibition of the intrinsic growth rate of all tumors and also a simultaneous partial inhibition of the growth deceleration rate in three of the 4 tumor lines. As result of this complex alteration the growth of most melanoma lines presently studied is ultimately stimulated by suramin treatment in vivo. However, one recently established line is an exception: in this tumor suramin did not significantly affect growth retardation and thus, led to an overall growth inhibition. One possible interpretation might be, that suramin simultaneously inhibits both the positive and the negative growth regulatory mechanisms of the tumors to different degrees leading to a new balance between them, which is expressed in a different growth pattern.

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Copy and paste a formatted citation
Spandidos Publications style
BASSUKAS I: ALTERATIONS OF THE IN-VIVO GROWTH-PATTERN OF XENOTRANSPLANTED HUMAN-MALIGNANT MELANOMAS AFTER SURAMIN TREATMENT IN NUDE-MICE. Oncol Rep 1: 981-986, 1994.
APA
BASSUKAS, I. (1994). ALTERATIONS OF THE IN-VIVO GROWTH-PATTERN OF XENOTRANSPLANTED HUMAN-MALIGNANT MELANOMAS AFTER SURAMIN TREATMENT IN NUDE-MICE. Oncology Reports, 1, 981-986. https://doi.org/10.3892/or.1.5.981
MLA
BASSUKAS, I."ALTERATIONS OF THE IN-VIVO GROWTH-PATTERN OF XENOTRANSPLANTED HUMAN-MALIGNANT MELANOMAS AFTER SURAMIN TREATMENT IN NUDE-MICE". Oncology Reports 1.5 (1994): 981-986.
Chicago
BASSUKAS, I."ALTERATIONS OF THE IN-VIVO GROWTH-PATTERN OF XENOTRANSPLANTED HUMAN-MALIGNANT MELANOMAS AFTER SURAMIN TREATMENT IN NUDE-MICE". Oncology Reports 1, no. 5 (1994): 981-986. https://doi.org/10.3892/or.1.5.981
Copy and paste a formatted citation
x
Spandidos Publications style
BASSUKAS I: ALTERATIONS OF THE IN-VIVO GROWTH-PATTERN OF XENOTRANSPLANTED HUMAN-MALIGNANT MELANOMAS AFTER SURAMIN TREATMENT IN NUDE-MICE. Oncol Rep 1: 981-986, 1994.
APA
BASSUKAS, I. (1994). ALTERATIONS OF THE IN-VIVO GROWTH-PATTERN OF XENOTRANSPLANTED HUMAN-MALIGNANT MELANOMAS AFTER SURAMIN TREATMENT IN NUDE-MICE. Oncology Reports, 1, 981-986. https://doi.org/10.3892/or.1.5.981
MLA
BASSUKAS, I."ALTERATIONS OF THE IN-VIVO GROWTH-PATTERN OF XENOTRANSPLANTED HUMAN-MALIGNANT MELANOMAS AFTER SURAMIN TREATMENT IN NUDE-MICE". Oncology Reports 1.5 (1994): 981-986.
Chicago
BASSUKAS, I."ALTERATIONS OF THE IN-VIVO GROWTH-PATTERN OF XENOTRANSPLANTED HUMAN-MALIGNANT MELANOMAS AFTER SURAMIN TREATMENT IN NUDE-MICE". Oncology Reports 1, no. 5 (1994): 981-986. https://doi.org/10.3892/or.1.5.981
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