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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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November 1994 Volume 1 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 1994 Volume 1 Issue 6

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Article

QUINOLONE PROPHYLAXIS IN NEUTROPENIC PATIENTS - EFFICACY VERSUS RESISTANCE

  • Authors:
    • M NUCCI
    • W PULCHERI
    • N SPECTOR
    • AP BUENO
    • S SILVEIRA
    • D MARANGONI
    • R FERREIRA
    • HP DEOLIVEIRA

  • View Affiliations / Copyright

    Affiliations: STATE UNIV RIO DE JANEIRO HOSP,BR-20551030 RIO JANEIRO,BRAZIL.
  • Pages: 1101-1105
    |
    Published online on: November 1, 1994
       https://doi.org/10.3892/or.1.6.1101
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Abstract

To assess the efficacy of quinolones in the prophylaxis of infections in neutropenic patients with acute non-lymphocytic leukemia, and to evaluate the emergence of quinolone resistance in two University Hospitals in Brazil, we retrospectively compared 101 consecutive episodes of neutropenia managed with quinolone prophylaxis between 1989 and November 1993, and 26 previous episodes without prophylaxis, and reviewed the results of in vitro sensitivity of Gram-negative strains to quinolones in the same period. Prophylaxis with quinolones resulted in less episodes of bacteremias (21% vs. 69%, p=10(-7)), including Gram-negative bacteremias (6% vs. 38%, p=10(-5)), with no statistically significant difference in the death rate (18% vs. 31%, p=0.14, 95% confidence interval -6-32). The resistance of Gramnegative strains to quinolones rose from 7% to 18% between 1990 and 1993 (p=10(-5)). The resistance against ceftazidime and amikacin, the agents used in the empirical antibiotic therapy, increased in the same proportion as the quinolones. Given the limited benefit of quinolones as prophylaxis and the increasing number of quinolone-resistant Gram-negative strains observed in our hospitals, the use of quinolones as prophylaxis must be seriously questioned. A stricter control of the use of quinolones in these hospitals might decrease resistance.

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Copy and paste a formatted citation
Spandidos Publications style
NUCCI M, PULCHERI W, SPECTOR N, BUENO A, SILVEIRA S, MARANGONI D, FERREIRA R and DEOLIVEIRA H: QUINOLONE PROPHYLAXIS IN NEUTROPENIC PATIENTS - EFFICACY VERSUS RESISTANCE. Oncol Rep 1: 1101-1105, 1994.
APA
NUCCI, M., PULCHERI, W., SPECTOR, N., BUENO, A., SILVEIRA, S., MARANGONI, D. ... DEOLIVEIRA, H. (1994). QUINOLONE PROPHYLAXIS IN NEUTROPENIC PATIENTS - EFFICACY VERSUS RESISTANCE. Oncology Reports, 1, 1101-1105. https://doi.org/10.3892/or.1.6.1101
MLA
NUCCI, M., PULCHERI, W., SPECTOR, N., BUENO, A., SILVEIRA, S., MARANGONI, D., FERREIRA, R., DEOLIVEIRA, H."QUINOLONE PROPHYLAXIS IN NEUTROPENIC PATIENTS - EFFICACY VERSUS RESISTANCE". Oncology Reports 1.6 (1994): 1101-1105.
Chicago
NUCCI, M., PULCHERI, W., SPECTOR, N., BUENO, A., SILVEIRA, S., MARANGONI, D., FERREIRA, R., DEOLIVEIRA, H."QUINOLONE PROPHYLAXIS IN NEUTROPENIC PATIENTS - EFFICACY VERSUS RESISTANCE". Oncology Reports 1, no. 6 (1994): 1101-1105. https://doi.org/10.3892/or.1.6.1101
Copy and paste a formatted citation
x
Spandidos Publications style
NUCCI M, PULCHERI W, SPECTOR N, BUENO A, SILVEIRA S, MARANGONI D, FERREIRA R and DEOLIVEIRA H: QUINOLONE PROPHYLAXIS IN NEUTROPENIC PATIENTS - EFFICACY VERSUS RESISTANCE. Oncol Rep 1: 1101-1105, 1994.
APA
NUCCI, M., PULCHERI, W., SPECTOR, N., BUENO, A., SILVEIRA, S., MARANGONI, D. ... DEOLIVEIRA, H. (1994). QUINOLONE PROPHYLAXIS IN NEUTROPENIC PATIENTS - EFFICACY VERSUS RESISTANCE. Oncology Reports, 1, 1101-1105. https://doi.org/10.3892/or.1.6.1101
MLA
NUCCI, M., PULCHERI, W., SPECTOR, N., BUENO, A., SILVEIRA, S., MARANGONI, D., FERREIRA, R., DEOLIVEIRA, H."QUINOLONE PROPHYLAXIS IN NEUTROPENIC PATIENTS - EFFICACY VERSUS RESISTANCE". Oncology Reports 1.6 (1994): 1101-1105.
Chicago
NUCCI, M., PULCHERI, W., SPECTOR, N., BUENO, A., SILVEIRA, S., MARANGONI, D., FERREIRA, R., DEOLIVEIRA, H."QUINOLONE PROPHYLAXIS IN NEUTROPENIC PATIENTS - EFFICACY VERSUS RESISTANCE". Oncology Reports 1, no. 6 (1994): 1101-1105. https://doi.org/10.3892/or.1.6.1101
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