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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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November 1994 Volume 1 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 1994 Volume 1 Issue 6

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Article

ALTERATIONS OF THE P53 TUMOR-SUPPRESSOR GENE AND KI-RAS ONCOGENE IN HUMAN PANCREATIC CANCER-DERIVED CELL-LINES WITH DIFFERENT METASTATIC POTENTIAL

  • Authors:
    • H IGUCHI
    • R MORITA
    • D YASUDA
    • R TAKAYANAGI
    • Y IKEDA
    • Y TAKADA
    • T SHIMAZOE
    • H NAWATA
    • A KONO

  • View Affiliations / Copyright

    Affiliations: SRL,HACHIOJI,TOKYO 192,JAPAN. KYUSHU UNIV,FAC MED,DEPT INTERNAL MED 3,FUKUOKA 812,JAPAN. KYUSHU NATL CANC CTR,DIV CHEMOTHERAPY,FUKUOKA 815,JAPAN.
  • Pages: 1223-1227
    |
    Published online on: November 1, 1994
       https://doi.org/10.3892/or.1.6.1223
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Abstract

Alterations of the p53 and Ki-ras genes were examined in 12 human pancreatic cancer-derived cell lines with different metastatic potential. Point mutations of the Ki-ras gene at codon 12 were found in 10 out of 12 cell lines (83%), while abnormalities of the p53 gene were identified in 8 out of 12 cell lines (67%) which included point mutations (n=7) and one base deletion (n=1). The comparison between alterations of the p53 and Ki-ras genes showed that all the 12 cell lines revealed alterations of both genes or one of these genes regardless of the metastatic potential. Further, same alterations of the Ki-ras gene or p53 gene were noted among the cell lines with increased metastatic potential and their parental cell lines. These findings suggest that alterations of the p53 gene, like the Ki-ras gene is a frequent event in pancreatic cancer, and could contribute cooperatively in the oncogenic steps of pancreatic cancer. It is also suggested that the genetic changes of the p53 and Ki-ras genes are not substantially associated with the metastatic potential in pancreatic cancer.

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Copy and paste a formatted citation
Spandidos Publications style
IGUCHI H, MORITA R, YASUDA D, TAKAYANAGI R, IKEDA Y, TAKADA Y, SHIMAZOE T, NAWATA H and KONO A: ALTERATIONS OF THE P53 TUMOR-SUPPRESSOR GENE AND KI-RAS ONCOGENE IN HUMAN PANCREATIC CANCER-DERIVED CELL-LINES WITH DIFFERENT METASTATIC POTENTIAL. Oncol Rep 1: 1223-1227, 1994.
APA
IGUCHI, H., MORITA, R., YASUDA, D., TAKAYANAGI, R., IKEDA, Y., TAKADA, Y. ... KONO, A. (1994). ALTERATIONS OF THE P53 TUMOR-SUPPRESSOR GENE AND KI-RAS ONCOGENE IN HUMAN PANCREATIC CANCER-DERIVED CELL-LINES WITH DIFFERENT METASTATIC POTENTIAL. Oncology Reports, 1, 1223-1227. https://doi.org/10.3892/or.1.6.1223
MLA
IGUCHI, H., MORITA, R., YASUDA, D., TAKAYANAGI, R., IKEDA, Y., TAKADA, Y., SHIMAZOE, T., NAWATA, H., KONO, A."ALTERATIONS OF THE P53 TUMOR-SUPPRESSOR GENE AND KI-RAS ONCOGENE IN HUMAN PANCREATIC CANCER-DERIVED CELL-LINES WITH DIFFERENT METASTATIC POTENTIAL". Oncology Reports 1.6 (1994): 1223-1227.
Chicago
IGUCHI, H., MORITA, R., YASUDA, D., TAKAYANAGI, R., IKEDA, Y., TAKADA, Y., SHIMAZOE, T., NAWATA, H., KONO, A."ALTERATIONS OF THE P53 TUMOR-SUPPRESSOR GENE AND KI-RAS ONCOGENE IN HUMAN PANCREATIC CANCER-DERIVED CELL-LINES WITH DIFFERENT METASTATIC POTENTIAL". Oncology Reports 1, no. 6 (1994): 1223-1227. https://doi.org/10.3892/or.1.6.1223
Copy and paste a formatted citation
x
Spandidos Publications style
IGUCHI H, MORITA R, YASUDA D, TAKAYANAGI R, IKEDA Y, TAKADA Y, SHIMAZOE T, NAWATA H and KONO A: ALTERATIONS OF THE P53 TUMOR-SUPPRESSOR GENE AND KI-RAS ONCOGENE IN HUMAN PANCREATIC CANCER-DERIVED CELL-LINES WITH DIFFERENT METASTATIC POTENTIAL. Oncol Rep 1: 1223-1227, 1994.
APA
IGUCHI, H., MORITA, R., YASUDA, D., TAKAYANAGI, R., IKEDA, Y., TAKADA, Y. ... KONO, A. (1994). ALTERATIONS OF THE P53 TUMOR-SUPPRESSOR GENE AND KI-RAS ONCOGENE IN HUMAN PANCREATIC CANCER-DERIVED CELL-LINES WITH DIFFERENT METASTATIC POTENTIAL. Oncology Reports, 1, 1223-1227. https://doi.org/10.3892/or.1.6.1223
MLA
IGUCHI, H., MORITA, R., YASUDA, D., TAKAYANAGI, R., IKEDA, Y., TAKADA, Y., SHIMAZOE, T., NAWATA, H., KONO, A."ALTERATIONS OF THE P53 TUMOR-SUPPRESSOR GENE AND KI-RAS ONCOGENE IN HUMAN PANCREATIC CANCER-DERIVED CELL-LINES WITH DIFFERENT METASTATIC POTENTIAL". Oncology Reports 1.6 (1994): 1223-1227.
Chicago
IGUCHI, H., MORITA, R., YASUDA, D., TAKAYANAGI, R., IKEDA, Y., TAKADA, Y., SHIMAZOE, T., NAWATA, H., KONO, A."ALTERATIONS OF THE P53 TUMOR-SUPPRESSOR GENE AND KI-RAS ONCOGENE IN HUMAN PANCREATIC CANCER-DERIVED CELL-LINES WITH DIFFERENT METASTATIC POTENTIAL". Oncology Reports 1, no. 6 (1994): 1223-1227. https://doi.org/10.3892/or.1.6.1223
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