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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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January-February 2003 Volume 10 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Amifostine as chemoprotectant in metastatic breast cancer patients treated with doxorubicin

  • Authors:
    • Annamaria Catino
    • Enrico Crucitta
    • Agnese Latorre
    • Domenico Sambiasi
    • Pietro Calabrese
    • Vito Lorusso

  • View Affiliations / Copyright

    Affiliations: Operative Unit of Medical Oncology, Oncology Institute of Bari, Bari, Italy
  • Pages: 163-167
    |
    Published online on: January 1, 2003
       https://doi.org/10.3892/or.10.1.163
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Abstract

Amifostine has shown to selectively protect normal tissues against cytotoxic and mutagenic effects of several anti-neoplastic drugs, such as alkylating agents, organoplatinum compounds, anthracyclines, taxanes, and ionising radiation. This cytoprotection is broad-spectrum and selective, without loss of therapeutic efficacy. In this study we have treated 31 patients affected with inoperable or metastatic breast cancer, not previously submitted to chemotherapy for advanced disease, with amifostine 910 mg/m2 followed by doxorubicin 75 mg/m2. The overall response rate was 52% with a median response duration of 13 months (range 6-53+) and a median overall survival of 21 months (range 3-59+). With regard to toxicity, 14 patients (45%) experienced transient g4 neutropenia which was febrile only in one case (3%). Grade 3-4 thrombocytopenia was not recorded. Nausea and vomiting occurred in 14% of cycles. Grade 3 mucositis was observed in only 1 patient, whereas 2 patients (6%) developed an asymptomatic drop of left ventricular ejection fraction (LVEF) >10% below basal value. In conclusion, this study suggests that amifostine can reduce doxorubicin related toxicity, thus improving the patients' quality of life and the efficacy/toxicity ratio of this drug.

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Copy and paste a formatted citation
Spandidos Publications style
Catino A, Crucitta E, Latorre A, Sambiasi D, Calabrese P and Lorusso V: Amifostine as chemoprotectant in metastatic breast cancer patients treated with doxorubicin. Oncol Rep 10: 163-167, 2003.
APA
Catino, A., Crucitta, E., Latorre, A., Sambiasi, D., Calabrese, P., & Lorusso, V. (2003). Amifostine as chemoprotectant in metastatic breast cancer patients treated with doxorubicin. Oncology Reports, 10, 163-167. https://doi.org/10.3892/or.10.1.163
MLA
Catino, A., Crucitta, E., Latorre, A., Sambiasi, D., Calabrese, P., Lorusso, V."Amifostine as chemoprotectant in metastatic breast cancer patients treated with doxorubicin". Oncology Reports 10.1 (2003): 163-167.
Chicago
Catino, A., Crucitta, E., Latorre, A., Sambiasi, D., Calabrese, P., Lorusso, V."Amifostine as chemoprotectant in metastatic breast cancer patients treated with doxorubicin". Oncology Reports 10, no. 1 (2003): 163-167. https://doi.org/10.3892/or.10.1.163
Copy and paste a formatted citation
x
Spandidos Publications style
Catino A, Crucitta E, Latorre A, Sambiasi D, Calabrese P and Lorusso V: Amifostine as chemoprotectant in metastatic breast cancer patients treated with doxorubicin. Oncol Rep 10: 163-167, 2003.
APA
Catino, A., Crucitta, E., Latorre, A., Sambiasi, D., Calabrese, P., & Lorusso, V. (2003). Amifostine as chemoprotectant in metastatic breast cancer patients treated with doxorubicin. Oncology Reports, 10, 163-167. https://doi.org/10.3892/or.10.1.163
MLA
Catino, A., Crucitta, E., Latorre, A., Sambiasi, D., Calabrese, P., Lorusso, V."Amifostine as chemoprotectant in metastatic breast cancer patients treated with doxorubicin". Oncology Reports 10.1 (2003): 163-167.
Chicago
Catino, A., Crucitta, E., Latorre, A., Sambiasi, D., Calabrese, P., Lorusso, V."Amifostine as chemoprotectant in metastatic breast cancer patients treated with doxorubicin". Oncology Reports 10, no. 1 (2003): 163-167. https://doi.org/10.3892/or.10.1.163
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