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Loss of heterozygosity on chromosome 16p and 18q in anaplastic thyroid carcinoma

  • Authors:
    • Masao Kadota
    • Yasuhiro Tamaki
    • Mitsugu Sekimoto
    • Yoshiyuki Fujiwara
    • Noriko Aritake
    • Seiichi Hasegawa
    • Tetsuro Kobayashi
    • Takayuki Ikeda
    • Akira Horii
    • Morito Monden

  • View Affiliations

  • Published online on: January 1, 2003     https://doi.org/10.3892/or.10.1.35
  • Pages: 35-38
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Abstract

The aim of this study was to clarify the genetic alterations in anaplastic transformation of the thyroid cancer. A total of 17 thyroid cancers including 7 anaplastic and 10 papillary cancers were analyzed for loss of heterozygosity (LOH) on chromosome 16p and 18q. All the samples from anaplastic cancer showed LOH at one or more loci out of ten markers on 16p, and only two showed one LOH at two loci out of five markers on 18q. No LOH was found on either 16p or 18q in papillary cancers. D16S423, D16S418 and D16s406 on 16p13.3 were the most frequently deleted loci in anaplastic cancers, and the region around these may harbor the putative tumor suppressor gene related to anaplastic transformation of thyroid cancer.

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January-February 2003
Volume 10 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Journal Metrics
  • Impact Factor: 4.2
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 8.4
  • CiteScore Rank: Q1: #68/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.786
  • SCImago Journal Rank (SJR): 0.812
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Spandidos Publications style
Kadota M, Tamaki Y, Sekimoto M, Fujiwara Y, Aritake N, Hasegawa S, Kobayashi T, Ikeda T, Horii A, Monden M, Monden M, et al: Loss of heterozygosity on chromosome 16p and 18q in anaplastic thyroid carcinoma. Oncol Rep 10: 35-38, 2003
APA
Kadota, M., Tamaki, Y., Sekimoto, M., Fujiwara, Y., Aritake, N., Hasegawa, S. ... Monden, M. (2003). Loss of heterozygosity on chromosome 16p and 18q in anaplastic thyroid carcinoma. Oncology Reports, 10, 35-38. https://doi.org/10.3892/or.10.1.35
MLA
Kadota, M., Tamaki, Y., Sekimoto, M., Fujiwara, Y., Aritake, N., Hasegawa, S., Kobayashi, T., Ikeda, T., Horii, A., Monden, M."Loss of heterozygosity on chromosome 16p and 18q in anaplastic thyroid carcinoma". Oncology Reports 10.1 (2003): 35-38.
Chicago
Kadota, M., Tamaki, Y., Sekimoto, M., Fujiwara, Y., Aritake, N., Hasegawa, S., Kobayashi, T., Ikeda, T., Horii, A., Monden, M."Loss of heterozygosity on chromosome 16p and 18q in anaplastic thyroid carcinoma". Oncology Reports 10, no. 1 (2003): 35-38. https://doi.org/10.3892/or.10.1.35