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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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January-February 2003 Volume 10 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

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Article

Differential expression patterns of hyaluronan receptors CD44 and RHAMM in transitional cell carcinomas of urinary bladder

  • Authors:
    • Qing-you Kong
    • Jia Liu
    • Xiao-Yan Chen
    • Xiao-Wei Wang
    • Yuan Sun
    • Hong Li

  • View Affiliations / Copyright

    Affiliations: Cancer Institute and Laboratory of Cell Biology and Molecular Genetics, College of Basic Medical Sciences, Dalian Medical University, 116027 Dalian, P.R. China
  • Pages: 51-55
    |
    Published online on: January 1, 2003
       https://doi.org/10.3892/or.10.1.51
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Abstract

Recurrence due to invasive growth is the major risk factor of transitional cell carcinoma (TCC) of urinary bladder. The interactions of hyaluronic acid (HA) and its receptors, CD44 and RHAMM, on cancer cells can promote invasion and metastasis but parallel study on these two genes in TCCs has not been available. The current work is aimed to address this issue by frozen tissue array-based immunocytochemical staining and Western blot hybridization. The results revealed that 19 out of 28 non-cancerous mucosa (68%) expressed CD44, in which 9 (33%) harbored variant exon 6 (v6). CD44 and v6 were both 5/11 (46%) in papillary, non-invasive carcinomas (pTa) and 6/14 (43%) in the tumors remained in sub-epithelial layer (pT1), while 5/29 (17%) and 3/29 (10%) in pT2-4 invasive tumors. RHAMM expression was uncommon in non-cancerous mucosa (5/28) but became frequent in pTa (9/11), pT1 (12/14) and pT2-4 (24/29) tumors. RHAMM proteins were labeled intracellularly and showed more than one isoforms. Our data further confirm the promising prognostic value of CD44 for TCC patients and demonstrate, for the first time, the correlation between RHAMM expression and malignant transformation of urothelial cells.

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Copy and paste a formatted citation
Spandidos Publications style
Kong Q, Liu J, Chen X, Wang X, Sun Y and Li H: Differential expression patterns of hyaluronan receptors CD44 and RHAMM in transitional cell carcinomas of urinary bladder. Oncol Rep 10: 51-55, 2003.
APA
Kong, Q., Liu, J., Chen, X., Wang, X., Sun, Y., & Li, H. (2003). Differential expression patterns of hyaluronan receptors CD44 and RHAMM in transitional cell carcinomas of urinary bladder. Oncology Reports, 10, 51-55. https://doi.org/10.3892/or.10.1.51
MLA
Kong, Q., Liu, J., Chen, X., Wang, X., Sun, Y., Li, H."Differential expression patterns of hyaluronan receptors CD44 and RHAMM in transitional cell carcinomas of urinary bladder". Oncology Reports 10.1 (2003): 51-55.
Chicago
Kong, Q., Liu, J., Chen, X., Wang, X., Sun, Y., Li, H."Differential expression patterns of hyaluronan receptors CD44 and RHAMM in transitional cell carcinomas of urinary bladder". Oncology Reports 10, no. 1 (2003): 51-55. https://doi.org/10.3892/or.10.1.51
Copy and paste a formatted citation
x
Spandidos Publications style
Kong Q, Liu J, Chen X, Wang X, Sun Y and Li H: Differential expression patterns of hyaluronan receptors CD44 and RHAMM in transitional cell carcinomas of urinary bladder. Oncol Rep 10: 51-55, 2003.
APA
Kong, Q., Liu, J., Chen, X., Wang, X., Sun, Y., & Li, H. (2003). Differential expression patterns of hyaluronan receptors CD44 and RHAMM in transitional cell carcinomas of urinary bladder. Oncology Reports, 10, 51-55. https://doi.org/10.3892/or.10.1.51
MLA
Kong, Q., Liu, J., Chen, X., Wang, X., Sun, Y., Li, H."Differential expression patterns of hyaluronan receptors CD44 and RHAMM in transitional cell carcinomas of urinary bladder". Oncology Reports 10.1 (2003): 51-55.
Chicago
Kong, Q., Liu, J., Chen, X., Wang, X., Sun, Y., Li, H."Differential expression patterns of hyaluronan receptors CD44 and RHAMM in transitional cell carcinomas of urinary bladder". Oncology Reports 10, no. 1 (2003): 51-55. https://doi.org/10.3892/or.10.1.51
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