Tamoxifen-induced non-alcoholic steatohepatitis in patients with breast cancer: Determination of a suitable biopsy site for diagnosis

  • Authors:
    • Yoriko Murata
    • Yasuhiro Ogawa
    • Toshiji Saibara
    • Akihito Nishioka
    • Naoko Takeuchi
    • Shinji Kariya
    • Saburo Onishi
    • Shoji Yoshida
  • View Affiliations

  • Published online on: January 1, 2003     https://doi.org/10.3892/or.10.1.97
  • Pages: 97-100
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Abstract

We have evaluated the distribution of fatty infiltration in the liver for determination of a suitable biopsy site for diagnosis of tamoxifen-induced non-alcoholic steatohepatitis (NASH) in patients with breast cancer. Thirty-eight consecutive breast cancer patients undergoing tamoxifen treatment were analyzed by CT to identify hepatic steatosis (HS) via calculation of the liver/spleen CT ratio in Couinaud's 8 areas. We defined hepatic fatty infiltration as a liver/spleen ratio of less than 0.9. The extent and distribution of the fatty infiltration was assessed using the liver/spleen ratio of the patients who had the lowest CT ratio below 0.9 in the 8 areas. Thirteen (34.2%) of the 38 patients had hepatic fatty infiltration. The liver/spleen ratios of each area differed significantly in all patients (p<0.0001). The CT ratio of these 13 patients was significantly lower in the right lobe than the left lobe (p<0.0001), although the ratios did not differ significantly among the 4 areas of the right lobe (p=0.52). Needle biopsy for diagnosis of NASH should be performed at the right lobe, which contains significantly more infiltrated fat than the left lobe in the liver.

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January-February 2003
Volume 10 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Murata Y, Ogawa Y, Saibara T, Nishioka A, Takeuchi N, Kariya S, Onishi S and Yoshida S: Tamoxifen-induced non-alcoholic steatohepatitis in patients with breast cancer: Determination of a suitable biopsy site for diagnosis. Oncol Rep 10: 97-100, 2003
APA
Murata, Y., Ogawa, Y., Saibara, T., Nishioka, A., Takeuchi, N., Kariya, S. ... Yoshida, S. (2003). Tamoxifen-induced non-alcoholic steatohepatitis in patients with breast cancer: Determination of a suitable biopsy site for diagnosis. Oncology Reports, 10, 97-100. https://doi.org/10.3892/or.10.1.97
MLA
Murata, Y., Ogawa, Y., Saibara, T., Nishioka, A., Takeuchi, N., Kariya, S., Onishi, S., Yoshida, S."Tamoxifen-induced non-alcoholic steatohepatitis in patients with breast cancer: Determination of a suitable biopsy site for diagnosis". Oncology Reports 10.1 (2003): 97-100.
Chicago
Murata, Y., Ogawa, Y., Saibara, T., Nishioka, A., Takeuchi, N., Kariya, S., Onishi, S., Yoshida, S."Tamoxifen-induced non-alcoholic steatohepatitis in patients with breast cancer: Determination of a suitable biopsy site for diagnosis". Oncology Reports 10, no. 1 (2003): 97-100. https://doi.org/10.3892/or.10.1.97