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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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November-December 2003 Volume 10 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

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Article

Detection of a novel alteration of the Axin gene in various pediatric neoplasms

  • Authors:
    • Jiangyong Miao
    • Takeshi Kusafuka
    • Akira Okada

  • View Affiliations / Copyright

    Affiliations: Department of Pediatric Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
  • Pages: 1943-1946
    |
    Published online on: November 1, 2003
       https://doi.org/10.3892/or.10.6.1943
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Abstract

The Wnt signaling pathway is conserved in various species from worms to mammals, and plays critical roles in development, cellular proliferation and differentiation. As part of Wnt signal transduction, the function of the Axin complex is inhibited, leading to the accumulation of β-catenin protein. Axin gene mutations have been detected in several kinds of human cancers. In this study, we investigated Axin gene alterations in a series of 58 pediatric neoplasms including neuroblastomas, teratomas, rhabdomyosarcomas. Forty-eight non-tumor tissues were used as a control series to compare gene alterations and their frequencies between tumors and normal tissues. The whole coding region of the Axin gene was examined by PCR-SSCP method using 24 sets of the primers. Samples revealing aberrant band patterns were subjected to direct sequencing analysis. In total, we identified six variants in the exons and four intronic nucleotide substitutions in the tumor series. Similar sequence variants except a rare sequence variant at codon 98 (CCG↷CTG) were observed in the control series and these were regarded as non-pathogenetic polymorphisms. Our results indicated that a tumor-associated mutation of the Axin gene is generally a rare event in our series of pediatric neoplasms.

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Copy and paste a formatted citation
Spandidos Publications style
Miao J, Kusafuka T and Okada A: Detection of a novel alteration of the Axin gene in various pediatric neoplasms. Oncol Rep 10: 1943-1946, 2003.
APA
Miao, J., Kusafuka, T., & Okada, A. (2003). Detection of a novel alteration of the Axin gene in various pediatric neoplasms. Oncology Reports, 10, 1943-1946. https://doi.org/10.3892/or.10.6.1943
MLA
Miao, J., Kusafuka, T., Okada, A."Detection of a novel alteration of the Axin gene in various pediatric neoplasms". Oncology Reports 10.6 (2003): 1943-1946.
Chicago
Miao, J., Kusafuka, T., Okada, A."Detection of a novel alteration of the Axin gene in various pediatric neoplasms". Oncology Reports 10, no. 6 (2003): 1943-1946. https://doi.org/10.3892/or.10.6.1943
Copy and paste a formatted citation
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Spandidos Publications style
Miao J, Kusafuka T and Okada A: Detection of a novel alteration of the Axin gene in various pediatric neoplasms. Oncol Rep 10: 1943-1946, 2003.
APA
Miao, J., Kusafuka, T., & Okada, A. (2003). Detection of a novel alteration of the Axin gene in various pediatric neoplasms. Oncology Reports, 10, 1943-1946. https://doi.org/10.3892/or.10.6.1943
MLA
Miao, J., Kusafuka, T., Okada, A."Detection of a novel alteration of the Axin gene in various pediatric neoplasms". Oncology Reports 10.6 (2003): 1943-1946.
Chicago
Miao, J., Kusafuka, T., Okada, A."Detection of a novel alteration of the Axin gene in various pediatric neoplasms". Oncology Reports 10, no. 6 (2003): 1943-1946. https://doi.org/10.3892/or.10.6.1943
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