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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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November-December 2003 Volume 10 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November-December 2003 Volume 10 Issue 6

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Article

Expression of transglutaminases in human breast cancer and their possible clinical significance

  • Authors:
    • Wen G. Jiang
    • Richard Ablin
    • Anthony Douglas-Jones
    • Robert E. Mansel

  • View Affiliations / Copyright

    Affiliations: Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Cardiff, CF14 4XN, UK. jiangw@cf.ac.uk
  • Pages: 2039-2044
    |
    Published online on: November 1, 2003
       https://doi.org/10.3892/or.10.6.2039
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Abstract

Implicated in several physiologic processes, including tumour-host, some transglutaminases (TGase) have been noted to play a regulatory role in the extracellular matrix in cell adhesion and migration of cancer cells. This study sought to determine the level of expression of TGases and their possible clinical significance in a cohort of human breast cancer patients using RT-PCR and quantitative RT-PCR. Normal breast tissues generally expressed low levels of TGases-1, 2, 3 and 7, and higher levels of TGases-4, 5 and plasma TGase (FXIII). Significantly increased levels of transcripts of TGases-4 and 7, and significantly lower levels of FXIII were seen in tumour tissues (n=110) compared with normal mammary tissues (n=27), p=0.05, 0.04 and 0.05, respectively. Node positive tumours exhibited significantly higher levels of TGase-2 and lower levels of TGase-3 (p=0.05 and 0.046, respectively). The lowest levels of TGases-3 and 7 were seen in patients with metastatic disease, and TGase-3 in patients who died of breast cancer, compared with those who remained disease-free (median follow-up 72 months). Higher levels of TGases-4 and 5 were noted in patients with local recurrence. Breast cancer displays an aberrant expression of TGases, wherein the levels of TGases-2, 3 and 7 have a relationship with node involvement and patient outcome.

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Copy and paste a formatted citation
Spandidos Publications style
Jiang WG, Ablin R, Douglas-Jones A and Mansel RE: Expression of transglutaminases in human breast cancer and their possible clinical significance. Oncol Rep 10: 2039-2044, 2003.
APA
Jiang, W.G., Ablin, R., Douglas-Jones, A., & Mansel, R.E. (2003). Expression of transglutaminases in human breast cancer and their possible clinical significance. Oncology Reports, 10, 2039-2044. https://doi.org/10.3892/or.10.6.2039
MLA
Jiang, W. G., Ablin, R., Douglas-Jones, A., Mansel, R. E."Expression of transglutaminases in human breast cancer and their possible clinical significance". Oncology Reports 10.6 (2003): 2039-2044.
Chicago
Jiang, W. G., Ablin, R., Douglas-Jones, A., Mansel, R. E."Expression of transglutaminases in human breast cancer and their possible clinical significance". Oncology Reports 10, no. 6 (2003): 2039-2044. https://doi.org/10.3892/or.10.6.2039
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang WG, Ablin R, Douglas-Jones A and Mansel RE: Expression of transglutaminases in human breast cancer and their possible clinical significance. Oncol Rep 10: 2039-2044, 2003.
APA
Jiang, W.G., Ablin, R., Douglas-Jones, A., & Mansel, R.E. (2003). Expression of transglutaminases in human breast cancer and their possible clinical significance. Oncology Reports, 10, 2039-2044. https://doi.org/10.3892/or.10.6.2039
MLA
Jiang, W. G., Ablin, R., Douglas-Jones, A., Mansel, R. E."Expression of transglutaminases in human breast cancer and their possible clinical significance". Oncology Reports 10.6 (2003): 2039-2044.
Chicago
Jiang, W. G., Ablin, R., Douglas-Jones, A., Mansel, R. E."Expression of transglutaminases in human breast cancer and their possible clinical significance". Oncology Reports 10, no. 6 (2003): 2039-2044. https://doi.org/10.3892/or.10.6.2039
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