p53 gene mutations are rare in human papillomavirus-associated colon cancer

  • Authors:
    • Nur Buyru
    • Metin Budak
    • Hulya Yazici
    • Nejat Dalay
  • View Affiliations

  • Published online on: November 1, 2003     https://doi.org/10.3892/or.10.6.2089
  • Pages: 2089-2092
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Recent studies suggest that infection with high risk human papillomavirus (HPV) is a common event in colon tumors. Infection by oncogenic HPV may result in functional inactivation of the p53 protein in absence of mutations. Thus far no studies have been made to examine the frequency of p53 mutations in HPV-associated colon cancer. The purpose of this study was to investigate the interrelationship between p53 mutations and HPV infection. The ‘hot-spot’ region of the p53 gene for mutations was analyzed by PCR-SSCP and direct sequencing in HPV-positive tumor samples. Only 2 mutations were identified in 56 samples. This rate was much lower than reported for sporadic colon tumors. Our results indicate an inverse relationship between p53 mutations and HPV infection and suggest that p53 inactivation caused by HPV infection may play a role in the pathogenesis of colon cancer.

Related Articles

Journal Cover

November-December 2003
Volume 10 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Buyru N, Budak M, Yazici H and Dalay N: p53 gene mutations are rare in human papillomavirus-associated colon cancer. Oncol Rep 10: 2089-2092, 2003.
APA
Buyru, N., Budak, M., Yazici, H., & Dalay, N. (2003). p53 gene mutations are rare in human papillomavirus-associated colon cancer. Oncology Reports, 10, 2089-2092. https://doi.org/10.3892/or.10.6.2089
MLA
Buyru, N., Budak, M., Yazici, H., Dalay, N."p53 gene mutations are rare in human papillomavirus-associated colon cancer". Oncology Reports 10.6 (2003): 2089-2092.
Chicago
Buyru, N., Budak, M., Yazici, H., Dalay, N."p53 gene mutations are rare in human papillomavirus-associated colon cancer". Oncology Reports 10, no. 6 (2003): 2089-2092. https://doi.org/10.3892/or.10.6.2089