Expression of protein kinase C isoenzymes in benign hyperplasia and carcinoma of prostate

  • Authors:
    • Rumelia Koren
    • David Ben Meir
    • Leah Langzam
    • Yoram Dekel
    • Miriam Konichezky
    • Jacob Baniel
    • Pinhas M. Livne
    • Rivka Gal
    • Sanford R. Sampson
  • View Affiliations

  • Published online on: February 1, 2004     https://doi.org/10.3892/or.11.2.321
  • Pages: 321-326
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Abstract

Protein kinase C family consists of 11 isoforms, classified into 3 categories according to their structure and mechanisms of activation. These isoenzymes are involved in processes, which maintain intracellular homeostasis. Alterations in activity, amount or distribution of protein kinase C (PKC) isoenzymes may cause cellular proliferation or induce apoptosis. We have studied and compared the expression levels of several PKC isoforms in benign prostatic hyperplasia (BPH) and prostate cancer (PCa). These are PKCs α (alpha), β (beta), δ (delta), ε (epsilon), ζ (zeta), η (eta), which have been detected as major isoforms in prostate tissue. Paraffin sections of 25 benign prostatic hyperplasia (BPH) and 25 of prostatic carcinoma (PCa) were examined for expression of PKC α, β, δ, ε, ζ, and η. Expression of PKC β was examined in additional 3 BPH and 3 PCa using Western blot analysis. We found a significant high level of expression of PKC isoforms α, β, ε and η in PCa compared to BPH (p<0.01). Using backward logistic regression, we found changes in PKC ε expression to be most significant between malignant compared to benign tumor tissue specimens. Immunostaining for PKCs α, β and η in addition to PKC ε may aid in distinguishing between benign and malignant prostatic disease.

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February 2004
Volume 11 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Koren R, Meir DB, Langzam L, Dekel Y, Konichezky M, Baniel J, Livne PM, Gal R and Sampson SR: Expression of protein kinase C isoenzymes in benign hyperplasia and carcinoma of prostate. Oncol Rep 11: 321-326, 2004
APA
Koren, R., Meir, D.B., Langzam, L., Dekel, Y., Konichezky, M., Baniel, J. ... Sampson, S.R. (2004). Expression of protein kinase C isoenzymes in benign hyperplasia and carcinoma of prostate. Oncology Reports, 11, 321-326. https://doi.org/10.3892/or.11.2.321
MLA
Koren, R., Meir, D. B., Langzam, L., Dekel, Y., Konichezky, M., Baniel, J., Livne, P. M., Gal, R., Sampson, S. R."Expression of protein kinase C isoenzymes in benign hyperplasia and carcinoma of prostate". Oncology Reports 11.2 (2004): 321-326.
Chicago
Koren, R., Meir, D. B., Langzam, L., Dekel, Y., Konichezky, M., Baniel, J., Livne, P. M., Gal, R., Sampson, S. R."Expression of protein kinase C isoenzymes in benign hyperplasia and carcinoma of prostate". Oncology Reports 11, no. 2 (2004): 321-326. https://doi.org/10.3892/or.11.2.321