Primary toremifene treatment for elderly postmenopausal women with breast cancer

  • Authors:
    • Norihiko Hamada
    • Yasuhiro Ogawa
    • Akihito Nishioka
    • Shinji Kariya
    • Shoji Yoshida
  • View Affiliations

  • Published online on: February 1, 2004     https://doi.org/10.3892/or.11.2.365
  • Pages: 365-370
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Abstract

Among patients with breast cancer who consulted the Department of Radiology, Kochi Medical School to undergo breast-conservation treatment, toremifene (TOR) alone was administered to 7 postmenopausal women as initial treatment for reasons such as the patient's desire, advanced age, and concomitant disease. In 6 patients, breast-conserving surgery was performed 1-12 months after the start of the administration of TOR alone. A 90-year-old patient has been treated with TOR alone for 56 months, and is being followed up. Six of 7 patients showed 50% or greater reduction of tumors, including 1 in whom the administration of TOR alone for 5 months reduced the tumor from a clinical diagnosis of skin invasion (T4b) to T1c, allowing lumpectomy under local anesthesia. In one patient, there were no changes (reduction ratio: 14%). No progressive disease was detected in any patient. In this study, the administration of TOR alone markedly reduced tumors in patients with estrogen receptor (ER)-positive breast cancer, facilitating down-staging. Treatment with TOR alone may be a useful neoadjuvant therapy or single therapy in elderly patients.

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February 2004
Volume 11 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Hamada N, Ogawa Y, Nishioka A, Kariya S and Yoshida S: Primary toremifene treatment for elderly postmenopausal women with breast cancer. Oncol Rep 11: 365-370, 2004
APA
Hamada, N., Ogawa, Y., Nishioka, A., Kariya, S., & Yoshida, S. (2004). Primary toremifene treatment for elderly postmenopausal women with breast cancer. Oncology Reports, 11, 365-370. https://doi.org/10.3892/or.11.2.365
MLA
Hamada, N., Ogawa, Y., Nishioka, A., Kariya, S., Yoshida, S."Primary toremifene treatment for elderly postmenopausal women with breast cancer". Oncology Reports 11.2 (2004): 365-370.
Chicago
Hamada, N., Ogawa, Y., Nishioka, A., Kariya, S., Yoshida, S."Primary toremifene treatment for elderly postmenopausal women with breast cancer". Oncology Reports 11, no. 2 (2004): 365-370. https://doi.org/10.3892/or.11.2.365