Ribozyme mediated down-regulation of thrombospondin receptor CD36 inhibits the growth of the human osteosarcoma cell line

  • Authors:
    • Hitoshi Yamazaki
    • Akiyoshi Handa
    • Masatake Nishi
    • Tetsuji Tokunaga
    • Masashi Tomisawa
    • Hiroyuki Hatanaka
    • Yoshiyuki Abe
    • Hiroshi Kijima
    • Yoshito Ueyama
    • Masato Nakamura
  • View Affiliations

  • Published online on: February 1, 2004     https://doi.org/10.3892/or.11.2.371
  • Pages: 371-374
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Abstract

Thrombospondin-1 (TSP1) is known to possess tumor suppressor functions. In contradiction, TSP1 enhances the stromal vascularization and growth of certain cancers. A cell adhesion receptor, CD36, has been shown to interact with a ligand TSP1. We studied how CD36 affects the growth of the osteosarcoma cell line (HOS) expressing TSP1. We used the anti-CD36 ribozyme to specifically suppress CD36 gene expression in the HOS. The expression of the CD36 mRNA was significantly suppressed in the ribozyme-introduced cell line (HOS/Rz). The transformant HOS/Rz markedly decreased its growth. The growth of the osteosarcoma cell line HOS may be regulated by autocrine or paracrine loop TSP1 and CD36.

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February 2004
Volume 11 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Yamazaki H, Handa A, Nishi M, Tokunaga T, Tomisawa M, Hatanaka H, Abe Y, Kijima H, Ueyama Y, Nakamura M, Nakamura M, et al: Ribozyme mediated down-regulation of thrombospondin receptor CD36 inhibits the growth of the human osteosarcoma cell line. Oncol Rep 11: 371-374, 2004
APA
Yamazaki, H., Handa, A., Nishi, M., Tokunaga, T., Tomisawa, M., Hatanaka, H. ... Nakamura, M. (2004). Ribozyme mediated down-regulation of thrombospondin receptor CD36 inhibits the growth of the human osteosarcoma cell line. Oncology Reports, 11, 371-374. https://doi.org/10.3892/or.11.2.371
MLA
Yamazaki, H., Handa, A., Nishi, M., Tokunaga, T., Tomisawa, M., Hatanaka, H., Abe, Y., Kijima, H., Ueyama, Y., Nakamura, M."Ribozyme mediated down-regulation of thrombospondin receptor CD36 inhibits the growth of the human osteosarcoma cell line". Oncology Reports 11.2 (2004): 371-374.
Chicago
Yamazaki, H., Handa, A., Nishi, M., Tokunaga, T., Tomisawa, M., Hatanaka, H., Abe, Y., Kijima, H., Ueyama, Y., Nakamura, M."Ribozyme mediated down-regulation of thrombospondin receptor CD36 inhibits the growth of the human osteosarcoma cell line". Oncology Reports 11, no. 2 (2004): 371-374. https://doi.org/10.3892/or.11.2.371