Trends in long-term survival following surgery for gastric cancer: A single institution experience

Inoue,Kentaro; Nakane,Yasushi; Michiura,Taku; Nakai,Koji; Sato,Mutsuya; Okumura,Syunichiro; Yamamichi,Keigo; Okamura,Shigeo; Imabayashi,Nobuyasu

doi:10.3892/or.11.2.459

February 2004 Volume 11 Issue 2

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February 2004 Volume 11 Issue 2

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Article

Trends in long-term survival following surgery for gastric cancer: A single institution experience

Authors:
- Kentaro Inoue
- Yasushi Nakane
- Taku Michiura
- Koji Nakai
- Mutsuya Sato
- Syunichiro Okumura
- Keigo Yamamichi
- Shigeo Okamura
- Nobuyasu Imabayashi
View Affiliations / Copyright

Affiliations: Second Department of Surgery, Kansai Medical University, Osaka 570-8507, Japan. inoueke@takii.kmu.ac.jp
Pages: 459-464
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Published online on: February 1, 2004

https://doi.org/10.3892/or.11.2.459
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Abstract

We reviewed cases at our institution in an attempt to identify temporal trends in survival of patients with operable gastric cancer. We analyzed data on 1632 patients who received a diagnosis of gastric adenocarcinoma between 1975 and 1995 and who underwent surgery at our institution. The time trends were examined by comparing three time periods (1975-1984, 1985-1989 and 1990-1995). Over time there was an improvement in the R0 resection rate: the rate significantly increased from 65% to 83%. Short-term outcomes following surgery have improved, with 30-day mortality dropping from 3.5% to 1%. The overall survival curve continuously improved with time. The five-year survival rates improved from 43% to 61%. The increased use of extended lymph node dissection with careful examination for metastases allowed for more accurate TNM staging. The incidence of peritoneal failure remains high, with peritoneal recurrence observed in 49% of the patients who underwent R0 resection between 1985 and 1995 and who experienced recurrences. Our results demonstrated that current efforts to improve gastric cancer management are finally meeting with noticeable success. However, advanced-stage cancer remains a medical problem. Multimodal treatment of advanced disease will be an important theme in coming years.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Trends in long-term survival following surgery for gastric cancer: A single institution experience

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Abstract

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