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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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April 2004 Volume 11 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Human PinX1, a potent telomerase inhibitor, is not involved in human gastrointestinal tract carcinoma

  • Authors:
    • Yuji Akiyama
    • Chihaya Maesawa
    • Kei Wada
    • Kentaro Fujisawa
    • Tetsuya Itabashi
    • Yoshinori Noda
    • Takehisa Honda
    • Nobuhiro Sato
    • Kaoru Ishida
    • Akinori Takagane
    • Kazuyoshi Saito
    • Tomoyuki Masuda

  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Iwate Medical University, School of Medicine, Morioka 020-8505, Japan
  • Pages: 871-874
    |
    Published online on: April 1, 2004
       https://doi.org/10.3892/or.11.4.871
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Abstract

PinX1 was isolated as a Pin2/TRF1 binding protein that also binds to the telomerase catalytic subunit hTERT. The gene is a potent telomerase inhibitor and a putative tumor suppressor since it inhibits telomerase activity and affects tumorigenicity in nude mice. This study investigated aberrations of PinX1 gene in gastrointestinal tract carcinomas (GITCs). We examined mutations, mRNA expression and promoter methylation of PinX1 gene in 15 GITC cell lines, and 20 patients with primary GITC. We found a missense mutation at codon 254 (AGC/TGC) in a colon and an esophageal carcinoma cell line, and in cancerous and matching normal tissues of 2 patients with primary GITC (10%). It might be a benign polymorphism. No hyper-methylation was found in the promoter region and the treatment by 5-Aza-2'-deoxycytidine did not affect PinX1 mRNA expression level in any of the cell lines. It was concluded that the human PinX1 does not affect tumorigenesis of human GITC.

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Copy and paste a formatted citation
Spandidos Publications style
Akiyama Y, Maesawa C, Wada K, Fujisawa K, Itabashi T, Noda Y, Honda T, Sato N, Ishida K, Takagane A, Takagane A, et al: Human PinX1, a potent telomerase inhibitor, is not involved in human gastrointestinal tract carcinoma. Oncol Rep 11: 871-874, 2004.
APA
Akiyama, Y., Maesawa, C., Wada, K., Fujisawa, K., Itabashi, T., Noda, Y. ... Masuda, T. (2004). Human PinX1, a potent telomerase inhibitor, is not involved in human gastrointestinal tract carcinoma. Oncology Reports, 11, 871-874. https://doi.org/10.3892/or.11.4.871
MLA
Akiyama, Y., Maesawa, C., Wada, K., Fujisawa, K., Itabashi, T., Noda, Y., Honda, T., Sato, N., Ishida, K., Takagane, A., Saito, K., Masuda, T."Human PinX1, a potent telomerase inhibitor, is not involved in human gastrointestinal tract carcinoma". Oncology Reports 11.4 (2004): 871-874.
Chicago
Akiyama, Y., Maesawa, C., Wada, K., Fujisawa, K., Itabashi, T., Noda, Y., Honda, T., Sato, N., Ishida, K., Takagane, A., Saito, K., Masuda, T."Human PinX1, a potent telomerase inhibitor, is not involved in human gastrointestinal tract carcinoma". Oncology Reports 11, no. 4 (2004): 871-874. https://doi.org/10.3892/or.11.4.871
Copy and paste a formatted citation
x
Spandidos Publications style
Akiyama Y, Maesawa C, Wada K, Fujisawa K, Itabashi T, Noda Y, Honda T, Sato N, Ishida K, Takagane A, Takagane A, et al: Human PinX1, a potent telomerase inhibitor, is not involved in human gastrointestinal tract carcinoma. Oncol Rep 11: 871-874, 2004.
APA
Akiyama, Y., Maesawa, C., Wada, K., Fujisawa, K., Itabashi, T., Noda, Y. ... Masuda, T. (2004). Human PinX1, a potent telomerase inhibitor, is not involved in human gastrointestinal tract carcinoma. Oncology Reports, 11, 871-874. https://doi.org/10.3892/or.11.4.871
MLA
Akiyama, Y., Maesawa, C., Wada, K., Fujisawa, K., Itabashi, T., Noda, Y., Honda, T., Sato, N., Ishida, K., Takagane, A., Saito, K., Masuda, T."Human PinX1, a potent telomerase inhibitor, is not involved in human gastrointestinal tract carcinoma". Oncology Reports 11.4 (2004): 871-874.
Chicago
Akiyama, Y., Maesawa, C., Wada, K., Fujisawa, K., Itabashi, T., Noda, Y., Honda, T., Sato, N., Ishida, K., Takagane, A., Saito, K., Masuda, T."Human PinX1, a potent telomerase inhibitor, is not involved in human gastrointestinal tract carcinoma". Oncology Reports 11, no. 4 (2004): 871-874. https://doi.org/10.3892/or.11.4.871
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