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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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April 2004 Volume 11 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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April 2004 Volume 11 Issue 4

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Article

Analysis of tumor suppressor p53 status in head and neck squamous cell carcinoma

  • Authors:
    • Jana Smardova
    • Katerina Ksicova
    • Hana Binkova
    • Antonin Krpensky
    • Sarka Pavlova
    • Jan Rottenberg
    • Hana Koukalova

  • View Affiliations / Copyright

    Affiliations: Department of Anatomy and Pathology, University Hospital Brno, 625 00 Brno, Czech Republic; janasmarda@seznam.cz
  • Pages: 923-929
    |
    Published online on: April 1, 2004
       https://doi.org/10.3892/or.11.4.923
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Abstract

Head and neck cancer belongs to the most common types of cancer in both males and females with a mortality rate of approximately 50%. More than 90% of head and neck cancers are squamous cell carcinoma (HNSCC). Carcinogenesis of this disease involves activation of proto-oncogenes and inactivation of tumor suppressor genes. Among them, aberrations of p53 tumor suppressor gene are common events. The aim of this study was to assess the frequency of the tumor suppressor p53 aberrations in Czech population by using a functional test in yeast (FASAY) and by two immunochemical methods. We compared results of the methods and assessed the relationship between the presence of p53 aberration and some clinico-pathological parameters. The following observations were made: i) the accumulated p53 protein was detected in 33 of 50 tested samples (66%) by immunohistochemical analysis and in 27 of 49 tested samples (55.1%) by immunoblotting; ii) the presence of p53 mutation was detected in 36 of 50 tested samples (72%); iii) 6 of 36 p53 mutations detected by FASAY were temperature sensitive (16.7%); iv) 2 independent p53 mutations were found in at least 2 of the 36 positive cases; v) no statistically significant relationship was found between p53 aberration and overall survival.

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Copy and paste a formatted citation
Spandidos Publications style
Smardova J, Ksicova K, Binkova H, Krpensky A, Pavlova S, Rottenberg J and Koukalova H: Analysis of tumor suppressor p53 status in head and neck squamous cell carcinoma. Oncol Rep 11: 923-929, 2004.
APA
Smardova, J., Ksicova, K., Binkova, H., Krpensky, A., Pavlova, S., Rottenberg, J., & Koukalova, H. (2004). Analysis of tumor suppressor p53 status in head and neck squamous cell carcinoma. Oncology Reports, 11, 923-929. https://doi.org/10.3892/or.11.4.923
MLA
Smardova, J., Ksicova, K., Binkova, H., Krpensky, A., Pavlova, S., Rottenberg, J., Koukalova, H."Analysis of tumor suppressor p53 status in head and neck squamous cell carcinoma". Oncology Reports 11.4 (2004): 923-929.
Chicago
Smardova, J., Ksicova, K., Binkova, H., Krpensky, A., Pavlova, S., Rottenberg, J., Koukalova, H."Analysis of tumor suppressor p53 status in head and neck squamous cell carcinoma". Oncology Reports 11, no. 4 (2004): 923-929. https://doi.org/10.3892/or.11.4.923
Copy and paste a formatted citation
x
Spandidos Publications style
Smardova J, Ksicova K, Binkova H, Krpensky A, Pavlova S, Rottenberg J and Koukalova H: Analysis of tumor suppressor p53 status in head and neck squamous cell carcinoma. Oncol Rep 11: 923-929, 2004.
APA
Smardova, J., Ksicova, K., Binkova, H., Krpensky, A., Pavlova, S., Rottenberg, J., & Koukalova, H. (2004). Analysis of tumor suppressor p53 status in head and neck squamous cell carcinoma. Oncology Reports, 11, 923-929. https://doi.org/10.3892/or.11.4.923
MLA
Smardova, J., Ksicova, K., Binkova, H., Krpensky, A., Pavlova, S., Rottenberg, J., Koukalova, H."Analysis of tumor suppressor p53 status in head and neck squamous cell carcinoma". Oncology Reports 11.4 (2004): 923-929.
Chicago
Smardova, J., Ksicova, K., Binkova, H., Krpensky, A., Pavlova, S., Rottenberg, J., Koukalova, H."Analysis of tumor suppressor p53 status in head and neck squamous cell carcinoma". Oncology Reports 11, no. 4 (2004): 923-929. https://doi.org/10.3892/or.11.4.923
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