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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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August 2004 Volume 12 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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August 2004 Volume 12 Issue 2

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Article

Constitutive activation of Stat3 correlates with increased expression of the c-Met/HGF receptor in oral squamous cell carcinoma

  • Authors:
    • Sebastian Krystian Klosek
    • Koh-Ichi Nakashiro
    • Shingo Hara
    • Chunnan Li
    • Satoru Shintani
    • Hiroyuki Hamakawa

  • View Affiliations / Copyright

    Affiliations: Department of Oral and Maxillofacial Surgery, Ehime University School of Medicine, Ehime 791-0295, Japan
  • Pages: 293-296
    |
    Published online on: August 1, 2004
       https://doi.org/10.3892/or.12.2.293
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Abstract

Stat3 belongs to a family of signal transducers and activators of transcription. Constitutive activation of Stat3 has been observed in many human malignancies. In addition, mutated Stat3 has been shown to possess oncogenic potential on its own, and activation of Stat3 signaling is required for HGF/c-Met-mediated tumorigenesis. In this study, we examined the correlation between Stat3 activation and HGF/c-Met signaling in samples of oral squamous cell carcinoma (OSCC). Immunohistochemical examination revealed the phosphorylated form of Stat3 in the nuclei of 62/84 OSCC tissue samples but not in normal mucosa, while c-Met expression was detected in 48 samples. Approximately half of the c-Met positive samples also contained phospho-Stat3. There were highly significant correlations between activation of Stat3 and c-Met expression (p=0.00097) and tumor stage. These results indicate that activation of Stat3 mediated by c-Met is frequently associated with the progression of OSCC.

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Copy and paste a formatted citation
Spandidos Publications style
Klosek SK, Nakashiro K, Hara S, Li C, Shintani S and Hamakawa H: Constitutive activation of Stat3 correlates with increased expression of the c-Met/HGF receptor in oral squamous cell carcinoma. Oncol Rep 12: 293-296, 2004.
APA
Klosek, S.K., Nakashiro, K., Hara, S., Li, C., Shintani, S., & Hamakawa, H. (2004). Constitutive activation of Stat3 correlates with increased expression of the c-Met/HGF receptor in oral squamous cell carcinoma. Oncology Reports, 12, 293-296. https://doi.org/10.3892/or.12.2.293
MLA
Klosek, S. K., Nakashiro, K., Hara, S., Li, C., Shintani, S., Hamakawa, H."Constitutive activation of Stat3 correlates with increased expression of the c-Met/HGF receptor in oral squamous cell carcinoma". Oncology Reports 12.2 (2004): 293-296.
Chicago
Klosek, S. K., Nakashiro, K., Hara, S., Li, C., Shintani, S., Hamakawa, H."Constitutive activation of Stat3 correlates with increased expression of the c-Met/HGF receptor in oral squamous cell carcinoma". Oncology Reports 12, no. 2 (2004): 293-296. https://doi.org/10.3892/or.12.2.293
Copy and paste a formatted citation
x
Spandidos Publications style
Klosek SK, Nakashiro K, Hara S, Li C, Shintani S and Hamakawa H: Constitutive activation of Stat3 correlates with increased expression of the c-Met/HGF receptor in oral squamous cell carcinoma. Oncol Rep 12: 293-296, 2004.
APA
Klosek, S.K., Nakashiro, K., Hara, S., Li, C., Shintani, S., & Hamakawa, H. (2004). Constitutive activation of Stat3 correlates with increased expression of the c-Met/HGF receptor in oral squamous cell carcinoma. Oncology Reports, 12, 293-296. https://doi.org/10.3892/or.12.2.293
MLA
Klosek, S. K., Nakashiro, K., Hara, S., Li, C., Shintani, S., Hamakawa, H."Constitutive activation of Stat3 correlates with increased expression of the c-Met/HGF receptor in oral squamous cell carcinoma". Oncology Reports 12.2 (2004): 293-296.
Chicago
Klosek, S. K., Nakashiro, K., Hara, S., Li, C., Shintani, S., Hamakawa, H."Constitutive activation of Stat3 correlates with increased expression of the c-Met/HGF receptor in oral squamous cell carcinoma". Oncology Reports 12, no. 2 (2004): 293-296. https://doi.org/10.3892/or.12.2.293
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