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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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August 2004 Volume 12 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Adenovirus-mediated HSV-TK gene therapy using the human telomerase promoter induced apoptosis of small cell lung cancer cell line

  • Authors:
    • Joon-Seok Song
    • Hyun-Pyo Kim

  • View Affiliations / Copyright

    Affiliations: Institute of Biotechnology, Korea University, Seoul 136-701, Korea. antibody@korea.ac.kr
  • Pages: 443-447
    |
    Published online on: August 1, 2004
       https://doi.org/10.3892/or.12.2.443
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Abstract

Telomerase is a ribonucleoprotein complex the function of which is to add telomeric repeats (TTAGGG)n to chromosomal ends, and it is known to play an important role in cellular immortalization. Telomerase is highly active in most tumor cells, but not in normal cells. As such, it may have possible applications in cancer gene therapy. Telomerase consists of two essential components, telomerase RNA template (hTR) and catalytic subunit (hTERT). hTERT is expressed only in cells and tissues positive for telomerase activity, i.e., tumor and fetal cells. We tested the possibility of the utilization of the hTERT promoter in targeted cancer gene therapy. We cloned the hTERT promoter in the place of the CMV promoter and sub-cloned HSV-TK gene to be controlled by hTERT gene promoter in adenovirus shuttle plasmid. Then we constructed recombinant adenovirus Ad-hT-TK, and infected them into a normal and a small cell lung cancer cell line. Through these experiments, we identified the selective tumor specific cell death by Ad-hT-TK. Furthermore, cell death detection ELISA and FACS analysis suggest that the reduced viability is mediated through the induction of apoptosis, indicating that this approach may be a useful method for suppressing cancer growth in targeted cancer gene therapy. These results show that Ad-hT-TK could be used for SCLC gene therapy.

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Copy and paste a formatted citation
Spandidos Publications style
Song J and Kim H: Adenovirus-mediated HSV-TK gene therapy using the human telomerase promoter induced apoptosis of small cell lung cancer cell line. Oncol Rep 12: 443-447, 2004.
APA
Song, J., & Kim, H. (2004). Adenovirus-mediated HSV-TK gene therapy using the human telomerase promoter induced apoptosis of small cell lung cancer cell line. Oncology Reports, 12, 443-447. https://doi.org/10.3892/or.12.2.443
MLA
Song, J., Kim, H."Adenovirus-mediated HSV-TK gene therapy using the human telomerase promoter induced apoptosis of small cell lung cancer cell line". Oncology Reports 12.2 (2004): 443-447.
Chicago
Song, J., Kim, H."Adenovirus-mediated HSV-TK gene therapy using the human telomerase promoter induced apoptosis of small cell lung cancer cell line". Oncology Reports 12, no. 2 (2004): 443-447. https://doi.org/10.3892/or.12.2.443
Copy and paste a formatted citation
x
Spandidos Publications style
Song J and Kim H: Adenovirus-mediated HSV-TK gene therapy using the human telomerase promoter induced apoptosis of small cell lung cancer cell line. Oncol Rep 12: 443-447, 2004.
APA
Song, J., & Kim, H. (2004). Adenovirus-mediated HSV-TK gene therapy using the human telomerase promoter induced apoptosis of small cell lung cancer cell line. Oncology Reports, 12, 443-447. https://doi.org/10.3892/or.12.2.443
MLA
Song, J., Kim, H."Adenovirus-mediated HSV-TK gene therapy using the human telomerase promoter induced apoptosis of small cell lung cancer cell line". Oncology Reports 12.2 (2004): 443-447.
Chicago
Song, J., Kim, H."Adenovirus-mediated HSV-TK gene therapy using the human telomerase promoter induced apoptosis of small cell lung cancer cell line". Oncology Reports 12, no. 2 (2004): 443-447. https://doi.org/10.3892/or.12.2.443
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