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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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January 2005 Volume 13 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Prognostic significance of cytoplasmic macrophage migration inhibitory factor expression in patients with squamous cell carcinoma of the head and neck treated with concurrent chemoradiotherapy

  • Authors:
    • Fumiyuki Suzuki
    • Yuji Nakamaru
    • Nobuhiko Oridate
    • Akihiro Homma
    • Tatsumi Nagahashi
    • Sanae Yamaguchi
    • Jun Nishihira
    • Yasushi Furuta
    • Satoshi Fukuda

  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan
  • Pages: 59-64
    |
    Published online on: January 1, 2005
       https://doi.org/10.3892/or.13.1.59
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Abstract

The macrophage migration inhibitory factor (MIF) is known to be a proinflammatory cytokine as well as a tumor growth regulator. Although the positive and negative effects of the MIF on tumor cell growth have been reported, the exact role of the MIF in tumorigenesis remains ambiguous. We examined the expression of the MIF protein in tumor specimens obtained from 50 head and neck squamous cell carcinoma (HNSCC) patients treated with concurrent chemoradiotherapy (carboplatin, 100 mg/m2), 4-7 times every week; a total radiation therapy dose of 65-75 Gy over 6.5-7.5 weeks, and determined whether the MIF level is related to clinical outcomes of these patients. Immunostaining with an MIF specific antibody was performed in formalin-fixed, paraffin-embedded specimens. The MIF protein was expressed to various extent in the tumor tissue specimens from the HNSCC patients. Prognostic analysis using the Kaplan-Meier method with regard to the MIF expression revealed that the patients with the MIF-negative tumors had a worse prognosis when compared to those with the MIF expression. The results of this study suggest that the intratumoral MIF expression has a prognostic value in HNSCC patients administered concurrent chemoradiotherapy.

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Copy and paste a formatted citation
Spandidos Publications style
Suzuki F, Nakamaru Y, Oridate N, Homma A, Nagahashi T, Yamaguchi S, Nishihira J, Furuta Y and Fukuda S: Prognostic significance of cytoplasmic macrophage migration inhibitory factor expression in patients with squamous cell carcinoma of the head and neck treated with concurrent chemoradiotherapy. Oncol Rep 13: 59-64, 2005.
APA
Suzuki, F., Nakamaru, Y., Oridate, N., Homma, A., Nagahashi, T., Yamaguchi, S. ... Fukuda, S. (2005). Prognostic significance of cytoplasmic macrophage migration inhibitory factor expression in patients with squamous cell carcinoma of the head and neck treated with concurrent chemoradiotherapy. Oncology Reports, 13, 59-64. https://doi.org/10.3892/or.13.1.59
MLA
Suzuki, F., Nakamaru, Y., Oridate, N., Homma, A., Nagahashi, T., Yamaguchi, S., Nishihira, J., Furuta, Y., Fukuda, S."Prognostic significance of cytoplasmic macrophage migration inhibitory factor expression in patients with squamous cell carcinoma of the head and neck treated with concurrent chemoradiotherapy". Oncology Reports 13.1 (2005): 59-64.
Chicago
Suzuki, F., Nakamaru, Y., Oridate, N., Homma, A., Nagahashi, T., Yamaguchi, S., Nishihira, J., Furuta, Y., Fukuda, S."Prognostic significance of cytoplasmic macrophage migration inhibitory factor expression in patients with squamous cell carcinoma of the head and neck treated with concurrent chemoradiotherapy". Oncology Reports 13, no. 1 (2005): 59-64. https://doi.org/10.3892/or.13.1.59
Copy and paste a formatted citation
x
Spandidos Publications style
Suzuki F, Nakamaru Y, Oridate N, Homma A, Nagahashi T, Yamaguchi S, Nishihira J, Furuta Y and Fukuda S: Prognostic significance of cytoplasmic macrophage migration inhibitory factor expression in patients with squamous cell carcinoma of the head and neck treated with concurrent chemoradiotherapy. Oncol Rep 13: 59-64, 2005.
APA
Suzuki, F., Nakamaru, Y., Oridate, N., Homma, A., Nagahashi, T., Yamaguchi, S. ... Fukuda, S. (2005). Prognostic significance of cytoplasmic macrophage migration inhibitory factor expression in patients with squamous cell carcinoma of the head and neck treated with concurrent chemoradiotherapy. Oncology Reports, 13, 59-64. https://doi.org/10.3892/or.13.1.59
MLA
Suzuki, F., Nakamaru, Y., Oridate, N., Homma, A., Nagahashi, T., Yamaguchi, S., Nishihira, J., Furuta, Y., Fukuda, S."Prognostic significance of cytoplasmic macrophage migration inhibitory factor expression in patients with squamous cell carcinoma of the head and neck treated with concurrent chemoradiotherapy". Oncology Reports 13.1 (2005): 59-64.
Chicago
Suzuki, F., Nakamaru, Y., Oridate, N., Homma, A., Nagahashi, T., Yamaguchi, S., Nishihira, J., Furuta, Y., Fukuda, S."Prognostic significance of cytoplasmic macrophage migration inhibitory factor expression in patients with squamous cell carcinoma of the head and neck treated with concurrent chemoradiotherapy". Oncology Reports 13, no. 1 (2005): 59-64. https://doi.org/10.3892/or.13.1.59
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