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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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March 2005 Volume 13 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

Mechanisms of antitumor action of methyl-3,5-diiodo-4-(4'-methoxyphenoxy)benzoate: Drug-induced protein dephosphorylations and inhibition of the permissive action of ceramide on growth factor induced cell proliferation

  • Authors:
    • Pal I. Bauer
    • Eva Kirsten
    • Ernest Kun

  • View Affiliations / Copyright

    Affiliations: Department of Medical Biochemistry, Semmelweis University, Budapest, Hungary
  • Pages: 465-468
    |
    Published online on: March 1, 2005
       https://doi.org/10.3892/or.13.3.465
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Abstract

The tumoricidal mechanism of methyl-3,5-diiodo-4-(4'-methoxypropoxy)benzoate (DIME), or DIPE, has been analyzed beyond its first recognized cellular site, which is the inhibition of tubulin polymerization. DIME (or DIPE) pretreatment of Eras cells for 3 days abolished ceramide basic fibroblast growth factor (bFGF)-induced glycolysis, coinciding with a block produced by the phosphoprotein dephosphorylation of cdc 25 by protein phosphatase 2A (PP2A). Protein dephosphorylation is directly activated by DIME (or DIPE), and enzyme activities that are dependent on P-proteins are significantly down-regulated (e.g. Topo I and II, MAP-kinase, and cdc-cyclin kinase). Purified PP2A is one target of activation by DIME (or DIPE), and an alkaline phosphatase isoenzyme is also induced by the drug. It is proposed that the pleiotropic effects of DIME (or DIPE) on cancer cells involve the activation of protein dephosphorylations, as well as inhibition of tubulin polymerization.

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Copy and paste a formatted citation
Spandidos Publications style
Bauer PI, Kirsten E and Kun E: Mechanisms of antitumor action of methyl-3,5-diiodo-4-(4'-methoxyphenoxy)benzoate: Drug-induced protein dephosphorylations and inhibition of the permissive action of ceramide on growth factor induced cell proliferation. Oncol Rep 13: 465-468, 2005.
APA
Bauer, P.I., Kirsten, E., & Kun, E. (2005). Mechanisms of antitumor action of methyl-3,5-diiodo-4-(4'-methoxyphenoxy)benzoate: Drug-induced protein dephosphorylations and inhibition of the permissive action of ceramide on growth factor induced cell proliferation. Oncology Reports, 13, 465-468. https://doi.org/10.3892/or.13.3.465
MLA
Bauer, P. I., Kirsten, E., Kun, E."Mechanisms of antitumor action of methyl-3,5-diiodo-4-(4'-methoxyphenoxy)benzoate: Drug-induced protein dephosphorylations and inhibition of the permissive action of ceramide on growth factor induced cell proliferation". Oncology Reports 13.3 (2005): 465-468.
Chicago
Bauer, P. I., Kirsten, E., Kun, E."Mechanisms of antitumor action of methyl-3,5-diiodo-4-(4'-methoxyphenoxy)benzoate: Drug-induced protein dephosphorylations and inhibition of the permissive action of ceramide on growth factor induced cell proliferation". Oncology Reports 13, no. 3 (2005): 465-468. https://doi.org/10.3892/or.13.3.465
Copy and paste a formatted citation
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Spandidos Publications style
Bauer PI, Kirsten E and Kun E: Mechanisms of antitumor action of methyl-3,5-diiodo-4-(4'-methoxyphenoxy)benzoate: Drug-induced protein dephosphorylations and inhibition of the permissive action of ceramide on growth factor induced cell proliferation. Oncol Rep 13: 465-468, 2005.
APA
Bauer, P.I., Kirsten, E., & Kun, E. (2005). Mechanisms of antitumor action of methyl-3,5-diiodo-4-(4'-methoxyphenoxy)benzoate: Drug-induced protein dephosphorylations and inhibition of the permissive action of ceramide on growth factor induced cell proliferation. Oncology Reports, 13, 465-468. https://doi.org/10.3892/or.13.3.465
MLA
Bauer, P. I., Kirsten, E., Kun, E."Mechanisms of antitumor action of methyl-3,5-diiodo-4-(4'-methoxyphenoxy)benzoate: Drug-induced protein dephosphorylations and inhibition of the permissive action of ceramide on growth factor induced cell proliferation". Oncology Reports 13.3 (2005): 465-468.
Chicago
Bauer, P. I., Kirsten, E., Kun, E."Mechanisms of antitumor action of methyl-3,5-diiodo-4-(4'-methoxyphenoxy)benzoate: Drug-induced protein dephosphorylations and inhibition of the permissive action of ceramide on growth factor induced cell proliferation". Oncology Reports 13, no. 3 (2005): 465-468. https://doi.org/10.3892/or.13.3.465
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