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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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March 2005 Volume 13 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March 2005 Volume 13 Issue 3

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Article

Combination of interferon and angiotensin-converting enzyme inhibitor, perindopril, suppresses liver carcinogenesis and angiogenesis in mice

  • Authors:
    • Hitoshi Yoshiji
    • Ryuichi Noguchi
    • Shigeki Kuriyama
    • Junichi Yoshii
    • Yasuhide Ikenaka

  • View Affiliations / Copyright

    Affiliations: Third Department of Internal Medicine, Nara Medical University, Shijo-cho 840, Kashihara, Nara 634-8522, Japan. yoshijih@naramed-u.ac.jp
  • Pages: 491-495
    |
    Published online on: March 1, 2005
       https://doi.org/10.3892/or.13.3.491
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Abstract

Angiogenesis is now recognized as playing a pivotal role in hepatocarcinogenesis. The aim of our current study was to examine the combination effect of the clinically used interferon-β (IFN) and angiotensin-converting enzyme inhibitor, perindopril (PE), on hepatocarcinogenesis induced by diethylnitrosamine, especially in conjunction with angiogenesis. Single treatment with either IFN or PE significantly attenuated the development of hepatocellular carcinoma (HCC), and the combination of IFN and PE nearly abolished hepatocarcinogenesis. Both IFN and PE also significantly suppressed the neovascularization and expression of the vascular endothelial growth factor (VEGF), a potent angiogenic factor, in the tumor. These inhibitory effects were similar in magnitude to their inhibitory effects against hepatocarcinogenesis. The combined treatment with IFN and PE resulted in a marked increase of apoptosis in the tumor, whereas tumor cell proliferation was not altered. These results suggested that the combination treatment with IFN and PE may be an effective new strategy for chemoprevention against HCC.

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Copy and paste a formatted citation
Spandidos Publications style
Yoshiji H, Noguchi R, Kuriyama S, Yoshii J and Ikenaka Y: Combination of interferon and angiotensin-converting enzyme inhibitor, perindopril, suppresses liver carcinogenesis and angiogenesis in mice. Oncol Rep 13: 491-495, 2005.
APA
Yoshiji, H., Noguchi, R., Kuriyama, S., Yoshii, J., & Ikenaka, Y. (2005). Combination of interferon and angiotensin-converting enzyme inhibitor, perindopril, suppresses liver carcinogenesis and angiogenesis in mice. Oncology Reports, 13, 491-495. https://doi.org/10.3892/or.13.3.491
MLA
Yoshiji, H., Noguchi, R., Kuriyama, S., Yoshii, J., Ikenaka, Y."Combination of interferon and angiotensin-converting enzyme inhibitor, perindopril, suppresses liver carcinogenesis and angiogenesis in mice". Oncology Reports 13.3 (2005): 491-495.
Chicago
Yoshiji, H., Noguchi, R., Kuriyama, S., Yoshii, J., Ikenaka, Y."Combination of interferon and angiotensin-converting enzyme inhibitor, perindopril, suppresses liver carcinogenesis and angiogenesis in mice". Oncology Reports 13, no. 3 (2005): 491-495. https://doi.org/10.3892/or.13.3.491
Copy and paste a formatted citation
x
Spandidos Publications style
Yoshiji H, Noguchi R, Kuriyama S, Yoshii J and Ikenaka Y: Combination of interferon and angiotensin-converting enzyme inhibitor, perindopril, suppresses liver carcinogenesis and angiogenesis in mice. Oncol Rep 13: 491-495, 2005.
APA
Yoshiji, H., Noguchi, R., Kuriyama, S., Yoshii, J., & Ikenaka, Y. (2005). Combination of interferon and angiotensin-converting enzyme inhibitor, perindopril, suppresses liver carcinogenesis and angiogenesis in mice. Oncology Reports, 13, 491-495. https://doi.org/10.3892/or.13.3.491
MLA
Yoshiji, H., Noguchi, R., Kuriyama, S., Yoshii, J., Ikenaka, Y."Combination of interferon and angiotensin-converting enzyme inhibitor, perindopril, suppresses liver carcinogenesis and angiogenesis in mice". Oncology Reports 13.3 (2005): 491-495.
Chicago
Yoshiji, H., Noguchi, R., Kuriyama, S., Yoshii, J., Ikenaka, Y."Combination of interferon and angiotensin-converting enzyme inhibitor, perindopril, suppresses liver carcinogenesis and angiogenesis in mice". Oncology Reports 13, no. 3 (2005): 491-495. https://doi.org/10.3892/or.13.3.491
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