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Mutational study of the 1p located genes p18ink4c, Patched-2, RIZ1 and KIF1B in oligodendrogliomas

  • Authors:
    • M. Eva Alonso
    • M. Josefa Bello
    • Dolores Arjona
    • Pilar Gonzalez-Gomez
    • Cinthia Amiñoso
    • Isabel Lopez-Marín
    • Jose M. de Campos
    • Alberto Isla
    • Jesús Vaquero
    • Manuel Gutierrez
    • Jose L. Sarasa
    • Juan A. Rey

  • View Affiliations

  • Published online on: March 1, 2005     https://doi.org/10.3892/or.13.3.539
  • Pages: 539-542
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Abstract

Loss of 1p heterozygosity is one of the most characteristic events in oligodendrogliomas. Several genes located in this region have been previously studied to find the target gene implicated in the development of this tumor without success. Patched-2, RIZ1 and KIF1B are novel oncosuppressor genes located at 1p and involved in different kinds of tumors. We have studied these genes and p18ink4c using PCR/SSCP methods to detect sequence variations in a series of 40 oligodendrogliomas in which the allelic status at 1p was analyzed. Polymorphisms or no sequence changes were detected in all four genes analyzed. None of the genes analyzed seem to be the target-gene mapped at 1p involved by mutation in oligodendroglioma development.

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March 2005
Volume 13 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Alonso ME, Bello MJ, Arjona D, Gonzalez-Gomez P, Amiñoso C, Lopez-Marín I, de Campos JM, Isla A, Vaquero J, Gutierrez M, Gutierrez M, et al: Mutational study of the 1p located genes p18ink4c, Patched-2, RIZ1 and KIF1B in oligodendrogliomas. Oncol Rep 13: 539-542, 2005
APA
Alonso, M.E., Bello, M.J., Arjona, D., Gonzalez-Gomez, P., Amiñoso, C., Lopez-Marín, I. ... Rey, J.A. (2005). Mutational study of the 1p located genes p18ink4c, Patched-2, RIZ1 and KIF1B in oligodendrogliomas. Oncology Reports, 13, 539-542. https://doi.org/10.3892/or.13.3.539
MLA
Alonso, M. E., Bello, M. J., Arjona, D., Gonzalez-Gomez, P., Amiñoso, C., Lopez-Marín, I., de Campos, J. M., Isla, A., Vaquero, J., Gutierrez, M., Sarasa, J. L., Rey, J. A."Mutational study of the 1p located genes p18ink4c, Patched-2, RIZ1 and KIF1B in oligodendrogliomas". Oncology Reports 13.3 (2005): 539-542.
Chicago
Alonso, M. E., Bello, M. J., Arjona, D., Gonzalez-Gomez, P., Amiñoso, C., Lopez-Marín, I., de Campos, J. M., Isla, A., Vaquero, J., Gutierrez, M., Sarasa, J. L., Rey, J. A."Mutational study of the 1p located genes p18ink4c, Patched-2, RIZ1 and KIF1B in oligodendrogliomas". Oncology Reports 13, no. 3 (2005): 539-542. https://doi.org/10.3892/or.13.3.539