E-cadherin, CD44s and CD44v6 correlate with tumour differentiation in colorectal cancer

  • Authors:
    • R. Bendardaf
    • A. Elzagheid
    • H. Lamlum
    • R. Ristamäki
    • Y. Collan
    • S. Pyrhönen
  • View Affiliations

  • Published online on: May 1, 2005     https://doi.org/10.3892/or.13.5.831
  • Pages: 831-835
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Abstract

Cell adhesion molecules (CAMs) are cell surface glycoproteins that are important in cell-cell and cell-matrix interactions and play an important role in cell growth and differentiation. We examined immunohistochemically CD44s, CD44v6 and E-cadherin expression in 86 formalin-fixed, paraffin-embedded primary tumours and 5 metastases. Lower levels of CD44s, CD44v6 and membranous E-cadherin expression were significantly associated with higher tumour grade (p=0.022, p=0.016 and p= 0.041, respectively). Moreover, CD44v6 and membranous E-cadherin expression were correlated with the depth of primary tumour invasion (p=0.030 and p=0.020, respectively), and increased expression of CD44v6 and decreased membranous E-cadherin expression were associated with increased primary tumour invasion. The results suggest that these CAMs are associated with tumour differentiation and invasion in locally advanced and metastatic colorectal carcinoma.

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May 2005
Volume 13 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Bendardaf R, Elzagheid A, Lamlum H, Ristamäki R, Collan Y and Pyrhönen S: E-cadherin, CD44s and CD44v6 correlate with tumour differentiation in colorectal cancer. Oncol Rep 13: 831-835, 2005
APA
Bendardaf, R., Elzagheid, A., Lamlum, H., Ristamäki, R., Collan, Y., & Pyrhönen, S. (2005). E-cadherin, CD44s and CD44v6 correlate with tumour differentiation in colorectal cancer. Oncology Reports, 13, 831-835. https://doi.org/10.3892/or.13.5.831
MLA
Bendardaf, R., Elzagheid, A., Lamlum, H., Ristamäki, R., Collan, Y., Pyrhönen, S."E-cadherin, CD44s and CD44v6 correlate with tumour differentiation in colorectal cancer". Oncology Reports 13.5 (2005): 831-835.
Chicago
Bendardaf, R., Elzagheid, A., Lamlum, H., Ristamäki, R., Collan, Y., Pyrhönen, S."E-cadherin, CD44s and CD44v6 correlate with tumour differentiation in colorectal cancer". Oncology Reports 13, no. 5 (2005): 831-835. https://doi.org/10.3892/or.13.5.831