Expression of matrix metalloproteinases (MMPs) in cultured hepatocellular carcinoma (HCC) cells and surgically resected HCC tissues

  • Authors:
    • Sachiko Ogasawara
    • Hirohisa Yano
    • Seiya Momosaki
    • Naoyo Nishida
    • Yumi Takemoto
    • Sakiko Kojiro
    • Masamichi Kojiro
  • View Affiliations

  • Published online on: June 1, 2005     https://doi.org/10.3892/or.13.6.1043
  • Pages: 1043-1048
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Abstract

Matrix metalloproteinases (MMPs) relate to the growth and infiltration of cancer cells, but the frequency and amount of their expression are not yet fully examined in hepatocellular carcinoma. Expression of MMPs (MMP-2, MMP-7, MMP-9, MT1-MMP, MT2-MMP, MT3-MMP) and tissue inhibitors of metalloproteinase (TIMP: TIMP-1, TIMP-2) was investigated on cultured hepatocellular carcinoma (HCC) cells and surgically resected HCC tissues. The cultured cells and tissues expressed MMPs and TIMPs at various degrees, and high expression was observed for MMP-2, MMP-9, MT1-MMP and TIMP-2. Expression of MMP-7, MT2-MMP and TIMP-1 was found at a low frequency and a low amount in both the cells and the tissues. MMP-2 was expressed in various cells: HCC cells, vascular wall and sinusoidal endothelial cells in the cancer area of surgically resected tissues; and hepatocytes, bile duct cells, vascular wall, macrophages and Kupffer cells in the non-cancerous area. MMPs and TIMPs were expressed at a relatively high frequency in hepatocytes of the cancerous area and surrounding non-cancerous area as well as in the other cells and tissues. MMPs and TIMPs may be involved in the progression of hepatocellular carcinoma including the infiltration of cancer cells.

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June 2005
Volume 13 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Ogasawara S, Yano H, Momosaki S, Nishida N, Takemoto Y, Kojiro S and Kojiro M: Expression of matrix metalloproteinases (MMPs) in cultured hepatocellular carcinoma (HCC) cells and surgically resected HCC tissues . Oncol Rep 13: 1043-1048, 2005.
APA
Ogasawara, S., Yano, H., Momosaki, S., Nishida, N., Takemoto, Y., Kojiro, S., & Kojiro, M. (2005). Expression of matrix metalloproteinases (MMPs) in cultured hepatocellular carcinoma (HCC) cells and surgically resected HCC tissues . Oncology Reports, 13, 1043-1048. https://doi.org/10.3892/or.13.6.1043
MLA
Ogasawara, S., Yano, H., Momosaki, S., Nishida, N., Takemoto, Y., Kojiro, S., Kojiro, M."Expression of matrix metalloproteinases (MMPs) in cultured hepatocellular carcinoma (HCC) cells and surgically resected HCC tissues ". Oncology Reports 13.6 (2005): 1043-1048.
Chicago
Ogasawara, S., Yano, H., Momosaki, S., Nishida, N., Takemoto, Y., Kojiro, S., Kojiro, M."Expression of matrix metalloproteinases (MMPs) in cultured hepatocellular carcinoma (HCC) cells and surgically resected HCC tissues ". Oncology Reports 13, no. 6 (2005): 1043-1048. https://doi.org/10.3892/or.13.6.1043