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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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June 2005 Volume 13 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

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Article

Up-regulation of growth factor receptor-bound protein 10 in cervical squamous cell carcinoma

  • Authors:
    • Keiko Okino
    • Hideki Konishi
    • Daisuke Doi
    • Koichi Yoneyama
    • Yujiro Ota
    • Enjing Jin
    • Oichi Kawanami
    • Toshiyuki Takeshita

  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan. k-ocky@nms.ac.jp
  • Pages: 1069-1074
    |
    Published online on: June 1, 2005
       https://doi.org/10.3892/or.13.6.1069
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Abstract

The Grb10 gene on chromosome 7p11.2-p12 belongs to a family of adapter proteins known to interact with a number of receptor tyrosine kinases, such as EGF, ErbB2/Her2, platelet-derived growth factor (PDGF), IGF-I receptors and vascular endothelial growth factor (VEGF) receptor, KDR (kinase insert domain containing receptor). In addition to receptor tyrosine kinases, Grb10 has also been found to interact with non-receptor tyrosine kinases such as Tec and Bcr-Abl, other cellular signaling molecules such as Raf-1, and the mitogen-activated protein (MAP) kinase, MEK. We demonstrated increased expression of Grb10 mRNA in more than one half of primary cervical squamous cell cancers (12 of 15 cases) when compared to corresponding non-cancerous uterine squamous cell tissues. In addition, immunohistochemical staining demonstrated that the Grb10 protein was prominent in the cytoplasm of cancer cells, whereas it was unreactive in the surrounding normal cervical squamous cells. In addition, its interruption by siRNA exhibited marked cell growth inhibition. These data indicate that amplification and increased expression of the Grb10 gene may play a role in the development of a portion of human cervical squamous cell cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Okino K, Konishi H, Doi D, Yoneyama K, Ota Y, Jin E, Kawanami O and Takeshita T: Up-regulation of growth factor receptor-bound protein 10 in cervical squamous cell carcinoma. Oncol Rep 13: 1069-1074, 2005.
APA
Okino, K., Konishi, H., Doi, D., Yoneyama, K., Ota, Y., Jin, E. ... Takeshita, T. (2005). Up-regulation of growth factor receptor-bound protein 10 in cervical squamous cell carcinoma. Oncology Reports, 13, 1069-1074. https://doi.org/10.3892/or.13.6.1069
MLA
Okino, K., Konishi, H., Doi, D., Yoneyama, K., Ota, Y., Jin, E., Kawanami, O., Takeshita, T."Up-regulation of growth factor receptor-bound protein 10 in cervical squamous cell carcinoma". Oncology Reports 13.6 (2005): 1069-1074.
Chicago
Okino, K., Konishi, H., Doi, D., Yoneyama, K., Ota, Y., Jin, E., Kawanami, O., Takeshita, T."Up-regulation of growth factor receptor-bound protein 10 in cervical squamous cell carcinoma". Oncology Reports 13, no. 6 (2005): 1069-1074. https://doi.org/10.3892/or.13.6.1069
Copy and paste a formatted citation
x
Spandidos Publications style
Okino K, Konishi H, Doi D, Yoneyama K, Ota Y, Jin E, Kawanami O and Takeshita T: Up-regulation of growth factor receptor-bound protein 10 in cervical squamous cell carcinoma. Oncol Rep 13: 1069-1074, 2005.
APA
Okino, K., Konishi, H., Doi, D., Yoneyama, K., Ota, Y., Jin, E. ... Takeshita, T. (2005). Up-regulation of growth factor receptor-bound protein 10 in cervical squamous cell carcinoma. Oncology Reports, 13, 1069-1074. https://doi.org/10.3892/or.13.6.1069
MLA
Okino, K., Konishi, H., Doi, D., Yoneyama, K., Ota, Y., Jin, E., Kawanami, O., Takeshita, T."Up-regulation of growth factor receptor-bound protein 10 in cervical squamous cell carcinoma". Oncology Reports 13.6 (2005): 1069-1074.
Chicago
Okino, K., Konishi, H., Doi, D., Yoneyama, K., Ota, Y., Jin, E., Kawanami, O., Takeshita, T."Up-regulation of growth factor receptor-bound protein 10 in cervical squamous cell carcinoma". Oncology Reports 13, no. 6 (2005): 1069-1074. https://doi.org/10.3892/or.13.6.1069
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