Role of hyaluronan and hyaluronan synthase in endometrial cancer

  • Authors:
    • Hiromitsu Yabushita
    • Tameko Kishida
    • Kanako Fusano
    • Kouhei Kanyama
    • Lisheng Zhuo
    • Naoki Itano
    • Koji Kimata
    • Masayoshi Noguchi
  • View Affiliations

  • Published online on: June 1, 2005     https://doi.org/10.3892/or.13.6.1101
  • Pages: 1101-1105
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Abstract

The aim of this study was to determine if the immunohistochemical expression of hyaluronan synthase (HAS) and serum levels of hyaluronan correlate with the clinicopathological manifestations of endometrial carcinoma. Sera were obtained from 59 endometrial cancer patients and 22 post-menopausal healthy women. Concentration of hyaluronan in sera was measured by an inhibitory ELISA using a hyaluronan-binding protein. Tissues obtained from 59 endometrial cancer patients were immunostained by the avidin-biotin-peroxidase complex method using anti-HAS1, anti-HAS2, anti-HAS3 and anti-CD44 antibody. A section was defined as having positive expression when >50% of the tumor cells were intensely stained. The expression of HAS1 was related to the depth of myometrial invasion, histological grade and lymph-vascular space involvement, but the expression of HAS2 and HAS3 was unrelated to these parameters. CD44 expression occurred more frequently in the HAS2- or HAS3-positive groups than in the HAS2- or HAS3-negative groups, and the expression of HAS1 was unrelated to CD44 expression. Serum levels of hyaluronan were higher in the endometrial cancer group than in the healthy control group, and increased with depth of myometrial invasion, histological grade and lymph-vascular space involvement. Serum hyaluronan levels were higher in the HAS1-positive group than in the HAS1-negative group, but the expression of HAS2 and HAS3 was unrelated to serum hyaluronan levels. HAS1 expression and an increase in serum hyaluronan in endometrial cancer may be associated with disease progression through myometrial invasion and lymph-vascular space involvement.

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June 2005
Volume 13 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Yabushita H, Kishida T, Fusano K, Kanyama K, Zhuo L, Itano N, Kimata K and Noguchi M: Role of hyaluronan and hyaluronan synthase in endometrial cancer. Oncol Rep 13: 1101-1105, 2005
APA
Yabushita, H., Kishida, T., Fusano, K., Kanyama, K., Zhuo, L., Itano, N. ... Noguchi, M. (2005). Role of hyaluronan and hyaluronan synthase in endometrial cancer. Oncology Reports, 13, 1101-1105. https://doi.org/10.3892/or.13.6.1101
MLA
Yabushita, H., Kishida, T., Fusano, K., Kanyama, K., Zhuo, L., Itano, N., Kimata, K., Noguchi, M."Role of hyaluronan and hyaluronan synthase in endometrial cancer". Oncology Reports 13.6 (2005): 1101-1105.
Chicago
Yabushita, H., Kishida, T., Fusano, K., Kanyama, K., Zhuo, L., Itano, N., Kimata, K., Noguchi, M."Role of hyaluronan and hyaluronan synthase in endometrial cancer". Oncology Reports 13, no. 6 (2005): 1101-1105. https://doi.org/10.3892/or.13.6.1101