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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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June 2005 Volume 13 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

The cell death process of the anticancer agent polysaccharide-peptide (PSP) in human promyelocytic leukemic HL-60 cells

  • Authors:
    • Xiaotong Yang
    • Wai-Hung Sit
    • Daniel Kwong-On Chan
    • Jennifer Man-Fan Wan

  • View Affiliations / Copyright

    Affiliations: Department of Zoology, Kadoorie Biological Sciences Building, The University of Hong Kong, Pokfalum Road, Hong Kong, SAR, P.R. China
  • Pages: 1201-1210
    |
    Published online on: June 1, 2005
       https://doi.org/10.3892/or.13.6.1201
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Abstract

The polysaccharide peptide (PSP) isolated from the mycelia of Chinese Medicinal fungus Coriolus versicolor has proven benefits in clinical trials in China but the mechanism of action has not been elucidated. In this study, HL-60 cell line was used to investigate the anti-proliferation and cell death process of PSP. The cytotoxicity of PSP on normal human T-lymphocytes was also evaluated. We show that PSP induced apoptosis of human promyelocytic leukemia HL-60 cells but not of normal human T-lymphocytes. The apoptotic machinery induced by PSP was associated with a decrease in Bcl-2/Bax ratio, drop in mitochondrial transmembrane potential, cytochrome c release, and activation of caspase-3, -8 and -9. Activation of the cellular apoptotic program is a current strategy for the treatment of human cancer, and the selectivity of PSP to induce apoptosis in cancerous and not on normal cells supports its development as a novel anticancer agent.

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Copy and paste a formatted citation
Spandidos Publications style
Yang X, Sit W, Chan DK and Wan JM: The cell death process of the anticancer agent polysaccharide-peptide (PSP) in human promyelocytic leukemic HL-60 cells . Oncol Rep 13: 1201-1210, 2005.
APA
Yang, X., Sit, W., Chan, D.K., & Wan, J.M. (2005). The cell death process of the anticancer agent polysaccharide-peptide (PSP) in human promyelocytic leukemic HL-60 cells . Oncology Reports, 13, 1201-1210. https://doi.org/10.3892/or.13.6.1201
MLA
Yang, X., Sit, W., Chan, D. K., Wan, J. M."The cell death process of the anticancer agent polysaccharide-peptide (PSP) in human promyelocytic leukemic HL-60 cells ". Oncology Reports 13.6 (2005): 1201-1210.
Chicago
Yang, X., Sit, W., Chan, D. K., Wan, J. M."The cell death process of the anticancer agent polysaccharide-peptide (PSP) in human promyelocytic leukemic HL-60 cells ". Oncology Reports 13, no. 6 (2005): 1201-1210. https://doi.org/10.3892/or.13.6.1201
Copy and paste a formatted citation
x
Spandidos Publications style
Yang X, Sit W, Chan DK and Wan JM: The cell death process of the anticancer agent polysaccharide-peptide (PSP) in human promyelocytic leukemic HL-60 cells . Oncol Rep 13: 1201-1210, 2005.
APA
Yang, X., Sit, W., Chan, D.K., & Wan, J.M. (2005). The cell death process of the anticancer agent polysaccharide-peptide (PSP) in human promyelocytic leukemic HL-60 cells . Oncology Reports, 13, 1201-1210. https://doi.org/10.3892/or.13.6.1201
MLA
Yang, X., Sit, W., Chan, D. K., Wan, J. M."The cell death process of the anticancer agent polysaccharide-peptide (PSP) in human promyelocytic leukemic HL-60 cells ". Oncology Reports 13.6 (2005): 1201-1210.
Chicago
Yang, X., Sit, W., Chan, D. K., Wan, J. M."The cell death process of the anticancer agent polysaccharide-peptide (PSP) in human promyelocytic leukemic HL-60 cells ". Oncology Reports 13, no. 6 (2005): 1201-1210. https://doi.org/10.3892/or.13.6.1201
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