Overexpression of survivin mRNA is associated with a favorable prognosis following neoadjuvant radiochemotherapy in esophageal cancer

  • Authors:
    • Ute Warnecke-Eberz
    • Shuichi Hokita
    • Huan Xi
    • Hiroshi Higashi
    • Stephan E. Baldus
    • Ralf Metzger
    • Jan Brabender
    • Elfriede Bollschweiler
    • Rolf P. Mueller
    • Hans P. Dienes
    • Arnulf H. Hoelscher
    • Paul M. Schneider
  • View Affiliations

  • Published online on: June 1, 2005     https://doi.org/10.3892/or.13.6.1241
  • Pages: 1241-1246
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Abstract

Survivin is a member of the inhibitor of apoptosis (IAP) gene family known to be involved in resistance to chemo- and radiation therapy. We examined the potential of quantitative survivin mRNA expression to predict histopathologic tumor response and prognosis following neoadjuvant radiochemotherapy (cis-platinum, 5-FU, 36 Gy) in patients with locally-advanced esophageal cancer (cT2-4, Nx, M0). Tumor (T) and normal tissue (N) samples from 51 patients were collected by endoscopic biopsy prior to treatment. Survivin mRNA expression was analyzed by quantitative real-time RT-PCR assays. Histomorphologic regression was defined as a major response when resected specimens contained <10% of residual vital tumor cells or if a pathologically complete response was achieved. Some 7/51 patients had progressive disease and 44/51 proceeded to surgical resection. Of 44 resected tumors, 17 (31.4%) showed a major and 27 (61.4%) showed a minor histopathologic response; the survival rates were significantly different (p<0.01). Median absolute survivin expression was 5.1 in the tumor and 2.4 in corresponding normal tissue samples (Wilcoxon, p<0.001). Median relative (T/N ratio) survivin mRNA expression was 1.7. Survivin mRNA expression levels did not show a significant association with histomorphologic regression. Relative survivin mRNA expression of a T/N ratio >1 indicated a favorable prognosis (log-rank, p<0.003). Expression levels of survivin mRNA in pretherapeutic biopsies did not predict the extent of histomorphologic tumor regression following preoperative radiochemotherapy for esophageal cancer. However, overexpression of survivin mRNA in pretreatment biopsies (T/N ratio >1) was associated with superior survival probabilities.

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June 2005
Volume 13 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Warnecke-Eberz U, Hokita S, Xi H, Higashi H, Baldus SE, Metzger R, Brabender J, Bollschweiler E, Mueller RP, Dienes HP, Dienes HP, et al: Overexpression of survivin mRNA is associated with a favorable prognosis following neoadjuvant radiochemotherapy in esophageal cancer. Oncol Rep 13: 1241-1246, 2005
APA
Warnecke-Eberz, U., Hokita, S., Xi, H., Higashi, H., Baldus, S.E., Metzger, R. ... Schneider, P.M. (2005). Overexpression of survivin mRNA is associated with a favorable prognosis following neoadjuvant radiochemotherapy in esophageal cancer. Oncology Reports, 13, 1241-1246. https://doi.org/10.3892/or.13.6.1241
MLA
Warnecke-Eberz, U., Hokita, S., Xi, H., Higashi, H., Baldus, S. E., Metzger, R., Brabender, J., Bollschweiler, E., Mueller, R. P., Dienes, H. P., Hoelscher, A. H., Schneider, P. M."Overexpression of survivin mRNA is associated with a favorable prognosis following neoadjuvant radiochemotherapy in esophageal cancer". Oncology Reports 13.6 (2005): 1241-1246.
Chicago
Warnecke-Eberz, U., Hokita, S., Xi, H., Higashi, H., Baldus, S. E., Metzger, R., Brabender, J., Bollschweiler, E., Mueller, R. P., Dienes, H. P., Hoelscher, A. H., Schneider, P. M."Overexpression of survivin mRNA is associated with a favorable prognosis following neoadjuvant radiochemotherapy in esophageal cancer". Oncology Reports 13, no. 6 (2005): 1241-1246. https://doi.org/10.3892/or.13.6.1241