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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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September 2005 Volume 14 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 2005 Volume 14 Issue 3

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Article

Analysis of glycoproteins in human colon cancers, normal tissues and in human colon carcinoma cells reactive with monoclonal antibody NCL-19-9

  • Authors:
    • Daniela Terracciano
    • Angela Mariano
    • Vincenzo Macchia
    • Angelina Di Carlo

  • View Affiliations / Copyright

    Affiliations: Dipartimento di Biologia e Patologia Cellulare e Molecolare L. Califano Università degli Studi di Napoli ‘Federico II,’ Via S. Pansini 5, I-80131 Napoli, Italy
  • Pages: 719-722
    |
    Published online on: September 1, 2005
       https://doi.org/10.3892/or.14.3.719
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Abstract

The expression of sialyl Lewisa antigen, also known as Ca 19-9, in colon cancer, normal tissues and LS174T human colon carcinoma cells were studied. In colon adenocarcinoma and cell plasma membranes this antigen is expressed on various glycoproteins with different molecular weights ranging in size from over 200 kDa to about 100 kDa. In addition, there is very low expression in peritumoral tissues. In cytosol and culture medium this epitope is carried by a single complex-glycoprotein with a very high molecular weight resembling a mucin. In cells the rise in cAMP levels elevate the synthesis and release of the carbohydrate antigen 19-9; whereas the treatment with 1,9-dideoxyforskolin, a diterpene, which does not activate adenylate cyclase, has no effect on content of the antigen. These results suggest that cAMP is involved on the expression of glycoprotein-associated sialyl Lewisa antigen in LS174T cells.

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Copy and paste a formatted citation
Spandidos Publications style
Terracciano D, Mariano A, Macchia V and Di Carlo A: Analysis of glycoproteins in human colon cancers, normal tissues and in human colon carcinoma cells reactive with monoclonal antibody NCL-19-9. Oncol Rep 14: 719-722, 2005.
APA
Terracciano, D., Mariano, A., Macchia, V., & Di Carlo, A. (2005). Analysis of glycoproteins in human colon cancers, normal tissues and in human colon carcinoma cells reactive with monoclonal antibody NCL-19-9. Oncology Reports, 14, 719-722. https://doi.org/10.3892/or.14.3.719
MLA
Terracciano, D., Mariano, A., Macchia, V., Di Carlo, A."Analysis of glycoproteins in human colon cancers, normal tissues and in human colon carcinoma cells reactive with monoclonal antibody NCL-19-9". Oncology Reports 14.3 (2005): 719-722.
Chicago
Terracciano, D., Mariano, A., Macchia, V., Di Carlo, A."Analysis of glycoproteins in human colon cancers, normal tissues and in human colon carcinoma cells reactive with monoclonal antibody NCL-19-9". Oncology Reports 14, no. 3 (2005): 719-722. https://doi.org/10.3892/or.14.3.719
Copy and paste a formatted citation
x
Spandidos Publications style
Terracciano D, Mariano A, Macchia V and Di Carlo A: Analysis of glycoproteins in human colon cancers, normal tissues and in human colon carcinoma cells reactive with monoclonal antibody NCL-19-9. Oncol Rep 14: 719-722, 2005.
APA
Terracciano, D., Mariano, A., Macchia, V., & Di Carlo, A. (2005). Analysis of glycoproteins in human colon cancers, normal tissues and in human colon carcinoma cells reactive with monoclonal antibody NCL-19-9. Oncology Reports, 14, 719-722. https://doi.org/10.3892/or.14.3.719
MLA
Terracciano, D., Mariano, A., Macchia, V., Di Carlo, A."Analysis of glycoproteins in human colon cancers, normal tissues and in human colon carcinoma cells reactive with monoclonal antibody NCL-19-9". Oncology Reports 14.3 (2005): 719-722.
Chicago
Terracciano, D., Mariano, A., Macchia, V., Di Carlo, A."Analysis of glycoproteins in human colon cancers, normal tissues and in human colon carcinoma cells reactive with monoclonal antibody NCL-19-9". Oncology Reports 14, no. 3 (2005): 719-722. https://doi.org/10.3892/or.14.3.719
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