Response to radiotherapy in brain metastases and survival of patients with non-small cell lung cancer

  • Authors:
    • Dimosthenis Antoniou
    • Kostas Kyprianou
    • George P. Stathopoulos
    • Christos Skarleas
    • Georgia Kolitsi
    • Marinos Veslemes
    • John Dimitroulis
    • Pantelis Giamboudakis
    • Kostas Marosis
    • Ourania Armenaki
    • C. Papageorgiou
    • Costas Katis
  • View Affiliations

  • Published online on: September 1, 2005     https://doi.org/10.3892/or.14.3.733
  • Pages: 733-736
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Abstract

The present study involves non-small cell lung (NSCLC) cancer patients with brain metastases, who were treated with radiation therapy, and our aim was to determine response rate and survival. A total of 167 patients were recruited, 155 (125 male, 30 female) of whom were evaluable. Performance status was 0-2 and histology or cytology included 66 (42.58%) adenocarcinomas, 62 (40.00%) undifferentiated and 27 (17.42%) squamous cell carcinomas. The stage of disease at diagnosis was IIIA-B in 92 (59.35%) patients and IV in 63 (40.65%). All patients had whole brain irradiation (3 Gy x5 days/week for 2 weeks to a total dose of 30 Gy), which was performed by a linear accelerator and a 6-MV photon beam. Objective response was observed in 59/155 (38.06%) patients with 17 (10.97%) complete and 42 (27.09%) partial responses, and median survival of 5 months for all patients [95% confidence interval (CI) 3.9-6.1]. Responders had statistically significant longer survival than non-responders. Although responders represented less than half of our patients with NSCLC and brain metastases, they had significantly longer survival.

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September 2005
Volume 14 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Antoniou D, Kyprianou K, Stathopoulos GP, Skarleas C, Kolitsi G, Veslemes M, Dimitroulis J, Giamboudakis P, Marosis K, Armenaki O, Armenaki O, et al: Response to radiotherapy in brain metastases and survival of patients with non-small cell lung cancer. Oncol Rep 14: 733-736, 2005
APA
Antoniou, D., Kyprianou, K., Stathopoulos, G.P., Skarleas, C., Kolitsi, G., Veslemes, M. ... Katis, C. (2005). Response to radiotherapy in brain metastases and survival of patients with non-small cell lung cancer. Oncology Reports, 14, 733-736. https://doi.org/10.3892/or.14.3.733
MLA
Antoniou, D., Kyprianou, K., Stathopoulos, G. P., Skarleas, C., Kolitsi, G., Veslemes, M., Dimitroulis, J., Giamboudakis, P., Marosis, K., Armenaki, O., Papageorgiou, C., Katis, C."Response to radiotherapy in brain metastases and survival of patients with non-small cell lung cancer". Oncology Reports 14.3 (2005): 733-736.
Chicago
Antoniou, D., Kyprianou, K., Stathopoulos, G. P., Skarleas, C., Kolitsi, G., Veslemes, M., Dimitroulis, J., Giamboudakis, P., Marosis, K., Armenaki, O., Papageorgiou, C., Katis, C."Response to radiotherapy in brain metastases and survival of patients with non-small cell lung cancer". Oncology Reports 14, no. 3 (2005): 733-736. https://doi.org/10.3892/or.14.3.733