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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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September 2005 Volume 14 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 2005 Volume 14 Issue 3

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Article

Generation of diverse mutated tumor antigen-specific cytotoxic T lymphocytes in a lung cancer patient with long survival

  • Authors:
    • Faten El Hage
    • Isabelle Vergnon
    • Dominique Grunenwald
    • Jean Charles Soria
    • Salem Chouaib
    • Fathia Mami-Chouaib

  • View Affiliations / Copyright

    Affiliations: Laboratoire Cytokines et Immunologie des Tumeurs Humaines, U487 INSERM, Institut Gustave Roussy, 39 rue Camille-Desmoulins, F-94 805 Villejuif, France
  • Pages: 763-769
    |
    Published online on: September 1, 2005
       https://doi.org/10.3892/or.14.3.763
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Abstract

We have identified an antigen recognized on a large cell carcinoma of the lung by tumor-specific cytotoxic T lymphocytes (CTL). The antigenic peptide is encoded by a mutated α-actinin-4 gene and presented by human leukocyte antigen (HLA)-A2. Using HLA-A2-peptide tetramers, we have derived from patient peripheral blood lymphocytes (PBL) and autologous tumor infiltrating lymphocytes (TIL) several mutated α-actinin-4-specific T cell clones. These clones displayed similar tetramer staining but distinct T cell receptor (TCR) usage and antitumor reactivity. Indeed, TIL clones lysed more efficiently the autologous tumor cells and released higher cytokine levels than PBL clones. Importantly, treatment of cancer cells with interferon-γ enhanced their susceptibility to PBL clone-mediated lysis correlated with increase in HLA-class I expression. The present findings provide evidence that an immune T cell response took place in a lung cancer patient with favorable clinical evolution and suggest that CTL, recognizing a truly tumor-specific antigen, may contribute to controlling the tumor.

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Copy and paste a formatted citation
Spandidos Publications style
El Hage F, Vergnon I, Grunenwald D, Soria JC, Chouaib S and Mami-Chouaib F: Generation of diverse mutated tumor antigen-specific cytotoxic T lymphocytes in a lung cancer patient with long survival. Oncol Rep 14: 763-769, 2005.
APA
El Hage, F., Vergnon, I., Grunenwald, D., Soria, J.C., Chouaib, S., & Mami-Chouaib, F. (2005). Generation of diverse mutated tumor antigen-specific cytotoxic T lymphocytes in a lung cancer patient with long survival. Oncology Reports, 14, 763-769. https://doi.org/10.3892/or.14.3.763
MLA
El Hage, F., Vergnon, I., Grunenwald, D., Soria, J. C., Chouaib, S., Mami-Chouaib, F."Generation of diverse mutated tumor antigen-specific cytotoxic T lymphocytes in a lung cancer patient with long survival". Oncology Reports 14.3 (2005): 763-769.
Chicago
El Hage, F., Vergnon, I., Grunenwald, D., Soria, J. C., Chouaib, S., Mami-Chouaib, F."Generation of diverse mutated tumor antigen-specific cytotoxic T lymphocytes in a lung cancer patient with long survival". Oncology Reports 14, no. 3 (2005): 763-769. https://doi.org/10.3892/or.14.3.763
Copy and paste a formatted citation
x
Spandidos Publications style
El Hage F, Vergnon I, Grunenwald D, Soria JC, Chouaib S and Mami-Chouaib F: Generation of diverse mutated tumor antigen-specific cytotoxic T lymphocytes in a lung cancer patient with long survival. Oncol Rep 14: 763-769, 2005.
APA
El Hage, F., Vergnon, I., Grunenwald, D., Soria, J.C., Chouaib, S., & Mami-Chouaib, F. (2005). Generation of diverse mutated tumor antigen-specific cytotoxic T lymphocytes in a lung cancer patient with long survival. Oncology Reports, 14, 763-769. https://doi.org/10.3892/or.14.3.763
MLA
El Hage, F., Vergnon, I., Grunenwald, D., Soria, J. C., Chouaib, S., Mami-Chouaib, F."Generation of diverse mutated tumor antigen-specific cytotoxic T lymphocytes in a lung cancer patient with long survival". Oncology Reports 14.3 (2005): 763-769.
Chicago
El Hage, F., Vergnon, I., Grunenwald, D., Soria, J. C., Chouaib, S., Mami-Chouaib, F."Generation of diverse mutated tumor antigen-specific cytotoxic T lymphocytes in a lung cancer patient with long survival". Oncology Reports 14, no. 3 (2005): 763-769. https://doi.org/10.3892/or.14.3.763
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