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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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March 2006 Volume 15 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Amurubicinol-induced eotaxin-3 expression in human NCI-H69 small cell lung carcinoma cells

  • Authors:
    • Masami Niiya
    • Kenji Niiya
    • Misako Shibakura
    • Noboru Asaumi
    • Chikamasa Yoshida
    • Mitsune Tanimoto

  • View Affiliations / Copyright

    Affiliations: Department of Medicine II, Faculty of Medicine, Okayama University Medical School, Okayama 700-8558, Japan. niiya7@yahoo.co.jp
  • Pages: 571-576
    |
    Published online on: March 1, 2006
       https://doi.org/10.3892/or.15.3.571
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Abstract

We previously demonstrated the doxorubicin-induced expression of urokinase-type plasminogen activator (uPA), interleukin-8 (IL-8), monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-α in human RC-K8 lymphoma cells and NCI-H69 small cell lung carcinoma cells in which reactive oxygen species might be involved. Amurubicin hydrochloride (AMR), a novel derivative drug of doxorubicin, was recently introduced to clinical practice for treatment of lung cancer in Japan. Therefore, we investigated the effects of AMR on the expression of uPA and chemokines in NCI-H69 cells. AMR and its active form, amurubicinol hydrochloride (AMROH), both induced the expression of uPA, IL-8 and MCP-1 in H69 cells in a dose-dependent manner. When the cultured supernatant obtained from AMR-treated H69 cells was subcutaneously injected into rabbits, migration of a significant number of eosinophils was observed around the injected site. Antigen levels of eotaxin-3, a major migration-factor of eosinophils, were increased in AMROH-treated cells in parallel with the mRNA levels. The induction was observed below the clinically achievable concentration of AMR or AMROH. Thus, the simultaneous induction of uPA, IL-8, MCP-1 and eotaxin-3 may play a role in the pharmacological action of AMR through induction of the interaction between proinflammatory cells and lung carcinoma cells.

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Copy and paste a formatted citation
Spandidos Publications style
Niiya M, Niiya K, Shibakura M, Asaumi N, Yoshida C and Tanimoto M: Amurubicinol-induced eotaxin-3 expression in human NCI-H69 small cell lung carcinoma cells. Oncol Rep 15: 571-576, 2006.
APA
Niiya, M., Niiya, K., Shibakura, M., Asaumi, N., Yoshida, C., & Tanimoto, M. (2006). Amurubicinol-induced eotaxin-3 expression in human NCI-H69 small cell lung carcinoma cells. Oncology Reports, 15, 571-576. https://doi.org/10.3892/or.15.3.571
MLA
Niiya, M., Niiya, K., Shibakura, M., Asaumi, N., Yoshida, C., Tanimoto, M."Amurubicinol-induced eotaxin-3 expression in human NCI-H69 small cell lung carcinoma cells". Oncology Reports 15.3 (2006): 571-576.
Chicago
Niiya, M., Niiya, K., Shibakura, M., Asaumi, N., Yoshida, C., Tanimoto, M."Amurubicinol-induced eotaxin-3 expression in human NCI-H69 small cell lung carcinoma cells". Oncology Reports 15, no. 3 (2006): 571-576. https://doi.org/10.3892/or.15.3.571
Copy and paste a formatted citation
x
Spandidos Publications style
Niiya M, Niiya K, Shibakura M, Asaumi N, Yoshida C and Tanimoto M: Amurubicinol-induced eotaxin-3 expression in human NCI-H69 small cell lung carcinoma cells. Oncol Rep 15: 571-576, 2006.
APA
Niiya, M., Niiya, K., Shibakura, M., Asaumi, N., Yoshida, C., & Tanimoto, M. (2006). Amurubicinol-induced eotaxin-3 expression in human NCI-H69 small cell lung carcinoma cells. Oncology Reports, 15, 571-576. https://doi.org/10.3892/or.15.3.571
MLA
Niiya, M., Niiya, K., Shibakura, M., Asaumi, N., Yoshida, C., Tanimoto, M."Amurubicinol-induced eotaxin-3 expression in human NCI-H69 small cell lung carcinoma cells". Oncology Reports 15.3 (2006): 571-576.
Chicago
Niiya, M., Niiya, K., Shibakura, M., Asaumi, N., Yoshida, C., Tanimoto, M."Amurubicinol-induced eotaxin-3 expression in human NCI-H69 small cell lung carcinoma cells". Oncology Reports 15, no. 3 (2006): 571-576. https://doi.org/10.3892/or.15.3.571
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