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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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March 2006 Volume 15 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Ethanol stimulates the secretion of matrix metalloproteinases 2 and 9 in MCF-7 human breast cancer cells

  • Authors:
    • Nicolas Etique
    • Isabelle Grillier-Vuissoz
    • Stephane Flament

  • View Affiliations / Copyright

    Affiliations: EA 3442 Aspects Cellulaires et Moléculaires de la Reproduction et du Dévelopement, Université Henri Poincaré - Nancy I, Faculté des Sciences, 54506 Vandoeuvre-lès-Nancy Cedex, France
  • Pages: 603-608
    |
    Published online on: March 1, 2006
       https://doi.org/10.3892/or.15.3.603
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Abstract

Alcohol consumption is a well-established risk factor for hormone-dependent breast cancer. In vitro studies performed to understand the mechanisms by which ethanol acts on breast cancer cells have shown that this compound stimulates both proliferation and migration. In the present study, we show by gelatin zymography that, when exposed to ethanol, MCF-7 human breast cancer cells display a higher amount of active metalloproteinases (MMP) 2 and 9 in their culture medium. This increase is somewhat higher than those observed in the case of 17β-estradiol (E2) exposure. As expected, anti-estrogen ICI 182,780 inhibits the E2-induced overexpression of a well-known estrogen responsive gene, the progesterone receptor, in MCF-7 cells. ICI 182,780 also inhibits the E2-induced increase in MMP-2 and -9 secretion. Nevertheless, in the case of ethanol exposure, this ER ant-agonist was only efficient on MMP-9 secretion. In addition, although MMP-9 transcription was not sensitive to E2 or ethanol, MMP-2 transcription was stimulated in MCF-7 cells exposed to ethanol. Collectively, these results give new insights into the effects of alcohol on breast cancer cell migration, which are not due solely to an estrogen-like activity of alcohol.

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Copy and paste a formatted citation
Spandidos Publications style
Etique N, Grillier-Vuissoz I and Flament S: Ethanol stimulates the secretion of matrix metalloproteinases 2 and 9 in MCF-7 human breast cancer cells. Oncol Rep 15: 603-608, 2006.
APA
Etique, N., Grillier-Vuissoz, I., & Flament, S. (2006). Ethanol stimulates the secretion of matrix metalloproteinases 2 and 9 in MCF-7 human breast cancer cells. Oncology Reports, 15, 603-608. https://doi.org/10.3892/or.15.3.603
MLA
Etique, N., Grillier-Vuissoz, I., Flament, S."Ethanol stimulates the secretion of matrix metalloproteinases 2 and 9 in MCF-7 human breast cancer cells". Oncology Reports 15.3 (2006): 603-608.
Chicago
Etique, N., Grillier-Vuissoz, I., Flament, S."Ethanol stimulates the secretion of matrix metalloproteinases 2 and 9 in MCF-7 human breast cancer cells". Oncology Reports 15, no. 3 (2006): 603-608. https://doi.org/10.3892/or.15.3.603
Copy and paste a formatted citation
x
Spandidos Publications style
Etique N, Grillier-Vuissoz I and Flament S: Ethanol stimulates the secretion of matrix metalloproteinases 2 and 9 in MCF-7 human breast cancer cells. Oncol Rep 15: 603-608, 2006.
APA
Etique, N., Grillier-Vuissoz, I., & Flament, S. (2006). Ethanol stimulates the secretion of matrix metalloproteinases 2 and 9 in MCF-7 human breast cancer cells. Oncology Reports, 15, 603-608. https://doi.org/10.3892/or.15.3.603
MLA
Etique, N., Grillier-Vuissoz, I., Flament, S."Ethanol stimulates the secretion of matrix metalloproteinases 2 and 9 in MCF-7 human breast cancer cells". Oncology Reports 15.3 (2006): 603-608.
Chicago
Etique, N., Grillier-Vuissoz, I., Flament, S."Ethanol stimulates the secretion of matrix metalloproteinases 2 and 9 in MCF-7 human breast cancer cells". Oncology Reports 15, no. 3 (2006): 603-608. https://doi.org/10.3892/or.15.3.603
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