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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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March 2006 Volume 15 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

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Article

p16 gene alterations in locally advanced squamous cell carcinoma of the head and neck

  • Authors:
    • Dian Wang
    • John C. Grecula
    • Reinhard A. Gahbauer
    • David E. Schuller
    • Kris R. Jatana
    • John D. Biancamano
    • James C. Lang

  • View Affiliations / Copyright

    Affiliations: Division of Radiation Oncology, Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA. dwang@radonc.mcw.edu
  • Pages: 661-665
    |
    Published online on: March 1, 2006
       https://doi.org/10.3892/or.15.3.661
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Abstract

We previously documented the presence of mutations/deletions in the tumor suppressor gene p16 in squamous cell carcinoma of the head and neck (SCCHN). However, the association of these p16 alterations with clinical outcome is unknown. In this study, RNA was isolated from 19 frozen SCCHN from 19 patients who were previously enrolled in the OSU intensification regimen 2. Quantitative real-time RT-PCR and direct sequencing analysis was then performed on the specimens to detect p16 gene alterations. Clinical outcome for each patient was updated and correlated with the p16 alterations found. Five tumor specimens were found to have no or very low expression of p16 when compared with normal tissue. The remaining 14 tumor samples demonstrated overexpression of p16 relative to the level of expression in normal tissue. Sequence analysis of the p16 RT-PCR product from these specimens allowed identification of mutational changes in the coding sequence of p16 in four of the SCCHN specimens. Subsequent analysis of clinical outcome associated with locoregional/distant failure demonstrated no correlation with either altered expression of p16 or mutational status of p16. Results from this study indicate that p16 alterations are frequently found in this cohort of SCCHN. However, p16 alterations alone do not appear to be associated with clinical outcome.

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Copy and paste a formatted citation
Spandidos Publications style
Wang D, Grecula JC, Gahbauer RA, Schuller DE, Jatana KR, Biancamano JD and Lang JC: p16 gene alterations in locally advanced squamous cell carcinoma of the head and neck. Oncol Rep 15: 661-665, 2006.
APA
Wang, D., Grecula, J.C., Gahbauer, R.A., Schuller, D.E., Jatana, K.R., Biancamano, J.D., & Lang, J.C. (2006). p16 gene alterations in locally advanced squamous cell carcinoma of the head and neck. Oncology Reports, 15, 661-665. https://doi.org/10.3892/or.15.3.661
MLA
Wang, D., Grecula, J. C., Gahbauer, R. A., Schuller, D. E., Jatana, K. R., Biancamano, J. D., Lang, J. C."p16 gene alterations in locally advanced squamous cell carcinoma of the head and neck". Oncology Reports 15.3 (2006): 661-665.
Chicago
Wang, D., Grecula, J. C., Gahbauer, R. A., Schuller, D. E., Jatana, K. R., Biancamano, J. D., Lang, J. C."p16 gene alterations in locally advanced squamous cell carcinoma of the head and neck". Oncology Reports 15, no. 3 (2006): 661-665. https://doi.org/10.3892/or.15.3.661
Copy and paste a formatted citation
x
Spandidos Publications style
Wang D, Grecula JC, Gahbauer RA, Schuller DE, Jatana KR, Biancamano JD and Lang JC: p16 gene alterations in locally advanced squamous cell carcinoma of the head and neck. Oncol Rep 15: 661-665, 2006.
APA
Wang, D., Grecula, J.C., Gahbauer, R.A., Schuller, D.E., Jatana, K.R., Biancamano, J.D., & Lang, J.C. (2006). p16 gene alterations in locally advanced squamous cell carcinoma of the head and neck. Oncology Reports, 15, 661-665. https://doi.org/10.3892/or.15.3.661
MLA
Wang, D., Grecula, J. C., Gahbauer, R. A., Schuller, D. E., Jatana, K. R., Biancamano, J. D., Lang, J. C."p16 gene alterations in locally advanced squamous cell carcinoma of the head and neck". Oncology Reports 15.3 (2006): 661-665.
Chicago
Wang, D., Grecula, J. C., Gahbauer, R. A., Schuller, D. E., Jatana, K. R., Biancamano, J. D., Lang, J. C."p16 gene alterations in locally advanced squamous cell carcinoma of the head and neck". Oncology Reports 15, no. 3 (2006): 661-665. https://doi.org/10.3892/or.15.3.661
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