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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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March 2006 Volume 15 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Radiation dose to testes and risk of infertility from radiotherapy for rectal cancer

  • Authors:
    • Michalis Mazonakis
    • John Damilakis
    • Haris Varveris
    • Nicholas Gourtsouiannis

  • View Affiliations / Copyright

    Affiliations: Department of Medical Physics, University Hospital of Iraklion, 71110 Iraklion, Crete, Greece
  • Pages: 729-733
    |
    Published online on: March 1, 2006
       https://doi.org/10.3892/or.15.3.729
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Abstract

This study aims to provide the means for testicular dose estimation from radiotherapy for rectal cancer. Rectal irradiation was simulated on a humanoid phantom using a 6 MV photon beam. The effect of field size, distance from irradiated area, wedge introduction into lateral beams, tissue thickness along the beam axis and use of gonad shields on the testicular dose was examined. Testicular dose was measured in five patients undergoing radiotherapy for rectal carcinoma. For a 4500 cGy tumour dose, testicular dose was 32-216 cGy depending upon the field dimensions and the distance from the field isocenter. The presence of wedges increased the testicular dose by a factor up to 2.2. The increase of irradiated tissue thickness increased the gonadal dose up to 40% whereas the use of the appropriate gonad shield reduced the dose by >66%. A simple method was developed to estimate testicular dose. The mean difference between the in vivo gonadal doses and the doses calculated using the proposed method was 5.8%. Testicular dose can exceed the value of 100 cGy, which permits a complete recovery of spermatogenesis. The presented data can be used to estimate the gonadal dose and the associated risk of infertility attributable to rectal irradiation.

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Copy and paste a formatted citation
Spandidos Publications style
Mazonakis M, Damilakis J, Varveris H and Gourtsouiannis N: Radiation dose to testes and risk of infertility from radiotherapy for rectal cancer. Oncol Rep 15: 729-733, 2006.
APA
Mazonakis, M., Damilakis, J., Varveris, H., & Gourtsouiannis, N. (2006). Radiation dose to testes and risk of infertility from radiotherapy for rectal cancer. Oncology Reports, 15, 729-733. https://doi.org/10.3892/or.15.3.729
MLA
Mazonakis, M., Damilakis, J., Varveris, H., Gourtsouiannis, N."Radiation dose to testes and risk of infertility from radiotherapy for rectal cancer". Oncology Reports 15.3 (2006): 729-733.
Chicago
Mazonakis, M., Damilakis, J., Varveris, H., Gourtsouiannis, N."Radiation dose to testes and risk of infertility from radiotherapy for rectal cancer". Oncology Reports 15, no. 3 (2006): 729-733. https://doi.org/10.3892/or.15.3.729
Copy and paste a formatted citation
x
Spandidos Publications style
Mazonakis M, Damilakis J, Varveris H and Gourtsouiannis N: Radiation dose to testes and risk of infertility from radiotherapy for rectal cancer. Oncol Rep 15: 729-733, 2006.
APA
Mazonakis, M., Damilakis, J., Varveris, H., & Gourtsouiannis, N. (2006). Radiation dose to testes and risk of infertility from radiotherapy for rectal cancer. Oncology Reports, 15, 729-733. https://doi.org/10.3892/or.15.3.729
MLA
Mazonakis, M., Damilakis, J., Varveris, H., Gourtsouiannis, N."Radiation dose to testes and risk of infertility from radiotherapy for rectal cancer". Oncology Reports 15.3 (2006): 729-733.
Chicago
Mazonakis, M., Damilakis, J., Varveris, H., Gourtsouiannis, N."Radiation dose to testes and risk of infertility from radiotherapy for rectal cancer". Oncology Reports 15, no. 3 (2006): 729-733. https://doi.org/10.3892/or.15.3.729
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