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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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September 2006 Volume 16 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 2006 Volume 16 Issue 3

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Article

Prognostic significance of Cyclin A in epidermoid anal cancer

  • Authors:
    • Per J. Nilsson
    • Claes Lenander
    • Carlos Rubio
    • Gert Auer
    • Olle Ljungqvist
    • Bengt Glimelius

  • View Affiliations / Copyright

    Affiliations: Centre of Gastrointestinal Disease, Ersta Hospital, SE 116 91 Stockholm, Sweden. perjohan.nilsson@erstadiakoni.se
  • Pages: 443-449
    |
    Published online on: September 1, 2006
       https://doi.org/10.3892/or.16.3.443
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Abstract

Ultimately aiming at a more individualized therapeutic approach in epidermoid anal cancer, this study explored the prognostic and predictive impact of a set of tumour markers. From a population-based cohort of 276 patients with epidermoid anal cancer, treated according to prospective protocols, 215 pre-treatment biopsies were investigated using immunohistochemistry. The expression of p53, p21, Cyclin A and CD31 was measured semi-quantitatively. The expression rate was classified as high when immunostaining was seen in >5% of the tumour cells for p53 and p21, >20% in Cyclin A and, above median vessel count for CD31. Marker expression was correlated to survival and treatment response. A high Cyclin A expression correlated significantly with improved overall (77% vs 59%, p=0.005) and tumour-specific (81% vs 64%, p=0.009) survival at 5 years. Also, the locoregional failure rate was significantly lower in patients with a high Cyclin A expression (12% vs 24%, p<0.05). In a multivariate Cox analysis Cyclin A was an independent prognostic factor. A low p21 expression correlated with a reduced rate of locoregional failure (14% vs 27%, p<0.05) but no impact on survival was found. For p53 and CD31 no significant correlations were obtained. Cyclin A may be an indicator of radiosensitivity and a valuable prognostic marker in epidermoid anal cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Nilsson PJ, Lenander C, Rubio C, Auer G, Ljungqvist O and Glimelius B: Prognostic significance of Cyclin A in epidermoid anal cancer. Oncol Rep 16: 443-449, 2006.
APA
Nilsson, P.J., Lenander, C., Rubio, C., Auer, G., Ljungqvist, O., & Glimelius, B. (2006). Prognostic significance of Cyclin A in epidermoid anal cancer. Oncology Reports, 16, 443-449. https://doi.org/10.3892/or.16.3.443
MLA
Nilsson, P. J., Lenander, C., Rubio, C., Auer, G., Ljungqvist, O., Glimelius, B."Prognostic significance of Cyclin A in epidermoid anal cancer". Oncology Reports 16.3 (2006): 443-449.
Chicago
Nilsson, P. J., Lenander, C., Rubio, C., Auer, G., Ljungqvist, O., Glimelius, B."Prognostic significance of Cyclin A in epidermoid anal cancer". Oncology Reports 16, no. 3 (2006): 443-449. https://doi.org/10.3892/or.16.3.443
Copy and paste a formatted citation
x
Spandidos Publications style
Nilsson PJ, Lenander C, Rubio C, Auer G, Ljungqvist O and Glimelius B: Prognostic significance of Cyclin A in epidermoid anal cancer. Oncol Rep 16: 443-449, 2006.
APA
Nilsson, P.J., Lenander, C., Rubio, C., Auer, G., Ljungqvist, O., & Glimelius, B. (2006). Prognostic significance of Cyclin A in epidermoid anal cancer. Oncology Reports, 16, 443-449. https://doi.org/10.3892/or.16.3.443
MLA
Nilsson, P. J., Lenander, C., Rubio, C., Auer, G., Ljungqvist, O., Glimelius, B."Prognostic significance of Cyclin A in epidermoid anal cancer". Oncology Reports 16.3 (2006): 443-449.
Chicago
Nilsson, P. J., Lenander, C., Rubio, C., Auer, G., Ljungqvist, O., Glimelius, B."Prognostic significance of Cyclin A in epidermoid anal cancer". Oncology Reports 16, no. 3 (2006): 443-449. https://doi.org/10.3892/or.16.3.443
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