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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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September 2006 Volume 16 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Potential application of GSTT1-null genotype in predicting toxicity associated to 5-fluouracil irinotecan and leucovorin regimen in advanced stage colorectal cancer patients

  • Authors:
    • R. Zárate Romero
    • R. Morales
    • F. Garcia
    • M. Huarriz
    • E. Bandres
    • J. De la Haba
    • A. Gómez
    • E. Aranda
    • J. García-Foncillas
  • View Affiliations / Copyright

    Affiliations: Laboratory of Biotechnology and Pharmacogenomics, Center for Applied Medical Research, University Clinic of Navarra, Navarra 31008, Spain. rzarate@unav.es
  • Pages: 497-503
    |
    Published online on: September 1, 2006
       https://doi.org/10.3892/or.16.3.497
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Abstract

Our aim was to evaluate the role of C-69T in GSTA1, Ile105Val in GSTP1, null allele in GSTT1 and GSTM1 in the prediction of toxicity in patients treated with 5-Fu/CPT-11/Lv regimens in metastatic CRC patients. Fifty-one patients with CRC metastatic disease were analysed. All patients had bidimensionally measurable disease according to WHO criteria. The gender distribution was 37 (74%) males and 13 (26%) females; age ranged from 41 to 71 years; performance status was in all patients ≥80 (Karnofsky index). The analysis of gene polymorphism was performed in lymphocytes by using PCR-RFLP (GSTA1, GSTP1), PCR (GSTT1, GSTM1) and sequencing analysis (UGT1A1∗28). An appreciable significant association was observed between the GSTT1-null and toxicity: 57% developed gastrointestinal toxicity grade III versus 23% of patients with GSTT1-present genotype (p=0.053). The other polymorphisms analysed did not show any significant relation with toxicity. Our data suggest that GSTT1-null is associated with a greater probability of developing toxicity to 5-Fu/CPT-11/Lv treatments, indicating a potential application of this genetic analysis in predicting adverse effects of this regimen.

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Copy and paste a formatted citation
Spandidos Publications style
Romero RZ, Morales R, Garcia F, Huarriz M, Bandres E, De la Haba J, Gómez A, Aranda E and García-Foncillas J: Potential application of GSTT1-null genotype in predicting toxicity associated to 5-fluouracil irinotecan and leucovorin regimen in advanced stage colorectal cancer patients. Oncol Rep 16: 497-503, 2006.
APA
Romero, R.Z., Morales, R., Garcia, F., Huarriz, M., Bandres, E., De la Haba, J. ... García-Foncillas, J. (2006). Potential application of GSTT1-null genotype in predicting toxicity associated to 5-fluouracil irinotecan and leucovorin regimen in advanced stage colorectal cancer patients. Oncology Reports, 16, 497-503. https://doi.org/10.3892/or.16.3.497
MLA
Romero, R. Z., Morales, R., Garcia, F., Huarriz, M., Bandres, E., De la Haba, J., Gómez, A., Aranda, E., García-Foncillas, J."Potential application of GSTT1-null genotype in predicting toxicity associated to 5-fluouracil irinotecan and leucovorin regimen in advanced stage colorectal cancer patients". Oncology Reports 16.3 (2006): 497-503.
Chicago
Romero, R. Z., Morales, R., Garcia, F., Huarriz, M., Bandres, E., De la Haba, J., Gómez, A., Aranda, E., García-Foncillas, J."Potential application of GSTT1-null genotype in predicting toxicity associated to 5-fluouracil irinotecan and leucovorin regimen in advanced stage colorectal cancer patients". Oncology Reports 16, no. 3 (2006): 497-503. https://doi.org/10.3892/or.16.3.497
Copy and paste a formatted citation
x
Spandidos Publications style
Romero RZ, Morales R, Garcia F, Huarriz M, Bandres E, De la Haba J, Gómez A, Aranda E and García-Foncillas J: Potential application of GSTT1-null genotype in predicting toxicity associated to 5-fluouracil irinotecan and leucovorin regimen in advanced stage colorectal cancer patients. Oncol Rep 16: 497-503, 2006.
APA
Romero, R.Z., Morales, R., Garcia, F., Huarriz, M., Bandres, E., De la Haba, J. ... García-Foncillas, J. (2006). Potential application of GSTT1-null genotype in predicting toxicity associated to 5-fluouracil irinotecan and leucovorin regimen in advanced stage colorectal cancer patients. Oncology Reports, 16, 497-503. https://doi.org/10.3892/or.16.3.497
MLA
Romero, R. Z., Morales, R., Garcia, F., Huarriz, M., Bandres, E., De la Haba, J., Gómez, A., Aranda, E., García-Foncillas, J."Potential application of GSTT1-null genotype in predicting toxicity associated to 5-fluouracil irinotecan and leucovorin regimen in advanced stage colorectal cancer patients". Oncology Reports 16.3 (2006): 497-503.
Chicago
Romero, R. Z., Morales, R., Garcia, F., Huarriz, M., Bandres, E., De la Haba, J., Gómez, A., Aranda, E., García-Foncillas, J."Potential application of GSTT1-null genotype in predicting toxicity associated to 5-fluouracil irinotecan and leucovorin regimen in advanced stage colorectal cancer patients". Oncology Reports 16, no. 3 (2006): 497-503. https://doi.org/10.3892/or.16.3.497
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