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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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February 2007 Volume 17 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Context of MUC1 epitope: Immunogenicity

  • Authors:
    • I. S. Quinlin
    • J. S. Burnside
    • K. E. Dombrowski
    • C. A. Phillips
    • N. Dolby
    • S. E. Wright

  • View Affiliations / Copyright

    Affiliations: Amarillo Veterans Affairs Medical Center, Amarillo, TX 79106, USA
  • Pages: 453-456
    |
    Published online on: February 1, 2007
       https://doi.org/10.3892/or.17.2.453
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Abstract

UC1 is a glycoprotein found at the secretory poles of normal cells but is hypoglycosylated on the entire surface of cell membranes of adenocarcinomas. In order to determine the influence on the immune response of peptide context for epitope presentation, peripheral blood mononuclear cells (PBMC) from patients with adenocarcinomas, were stimulated with MUC1 peptides derived from the 20 amino acids (aa) long sequence that is characteristic of the MUC1 Variable Number of Tandem Repeats (VNTR). In the seven peptides tested, the T-cell tumor-specific epitope (cTSE) was surrounded by variable numbers of aa and repeated up to 5 times in the same peptide. The results of this study indicate that cultures stimulated with peptide 610 (GSTAPPAHGVTS APDTRPAP) showed the highest specific killing of the MUC1-expressing breast cancer MCF-7 cells. Peptide 610 is also superior to the other peptides in inducing better production of the type 1 cytokines, tissue necrosis factor α and interferon γ. In conclusion, context of the epitope and not sequence alone determines immunogenicity.

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Copy and paste a formatted citation
Spandidos Publications style
Quinlin IS, Burnside JS, Dombrowski KE, Phillips CA, Dolby N and Wright SE: Context of MUC1 epitope: Immunogenicity. Oncol Rep 17: 453-456, 2007.
APA
Quinlin, I.S., Burnside, J.S., Dombrowski, K.E., Phillips, C.A., Dolby, N., & Wright, S.E. (2007). Context of MUC1 epitope: Immunogenicity. Oncology Reports, 17, 453-456. https://doi.org/10.3892/or.17.2.453
MLA
Quinlin, I. S., Burnside, J. S., Dombrowski, K. E., Phillips, C. A., Dolby, N., Wright, S. E."Context of MUC1 epitope: Immunogenicity". Oncology Reports 17.2 (2007): 453-456.
Chicago
Quinlin, I. S., Burnside, J. S., Dombrowski, K. E., Phillips, C. A., Dolby, N., Wright, S. E."Context of MUC1 epitope: Immunogenicity". Oncology Reports 17, no. 2 (2007): 453-456. https://doi.org/10.3892/or.17.2.453
Copy and paste a formatted citation
x
Spandidos Publications style
Quinlin IS, Burnside JS, Dombrowski KE, Phillips CA, Dolby N and Wright SE: Context of MUC1 epitope: Immunogenicity. Oncol Rep 17: 453-456, 2007.
APA
Quinlin, I.S., Burnside, J.S., Dombrowski, K.E., Phillips, C.A., Dolby, N., & Wright, S.E. (2007). Context of MUC1 epitope: Immunogenicity. Oncology Reports, 17, 453-456. https://doi.org/10.3892/or.17.2.453
MLA
Quinlin, I. S., Burnside, J. S., Dombrowski, K. E., Phillips, C. A., Dolby, N., Wright, S. E."Context of MUC1 epitope: Immunogenicity". Oncology Reports 17.2 (2007): 453-456.
Chicago
Quinlin, I. S., Burnside, J. S., Dombrowski, K. E., Phillips, C. A., Dolby, N., Wright, S. E."Context of MUC1 epitope: Immunogenicity". Oncology Reports 17, no. 2 (2007): 453-456. https://doi.org/10.3892/or.17.2.453
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