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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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February 2007 Volume 17 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 2007 Volume 17 Issue 2

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Article

Relationship between COPD and polymorphisms of HOX-1 and mEPH in a Chinese population

  • Authors:
    • Wei-Ping Fu
    • Chang Sun
    • Lu-Ming Dai
    • Li-Fen Yang
    • Ya-Ping Zhang

  • View Affiliations / Copyright

    Affiliations: Laboratory for Conservation and Utilization of Bio-resource, Yunnan University, Kunming 650091, P.R. China
  • Pages: 483-488
    |
    Published online on: February 1, 2007
       https://doi.org/10.3892/or.17.2.483
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Abstract

Recent studies have proposed that susceptibility to chronic obstructive pulmonary disease (COPD) might be related with the polymorphisms of some genes encoding antioxidant enzymes, such as heme oxygenase-1 (HOX-1) and microsomal epoxide hydrolase (mEPH). We examined these polymorphisms in 256 patients with COPD and 266 healthy smokers from Han population in Southwest China. The frequencies of each allele were compared both individually and in combination between patients and controls. Polymorphisms of HOX-1 gene could be grouped into three classes: S (≤25 repeat), M (26-31 repeat), and L (≥32 repeat). The allele frequencies of class L and the genotypic frequencies of the group with L were significantly higher in COPD than in controls. Our findings also showed that the proportion of slow mEPH activity was significantly higher in COPD than in controls. Conversely, the proportion of fast mEPH activity was significantly lower in COPD. In combined analysis, the frequency of the individuals having at least one L allele in the HOX-1 gene promoter and slow or very slow activity genotype for mEPH was higher in COPD than in control. Genetic polymorphisms in HOX-1 and mEPH genes are associated with the development of COPD in Southwest China.

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Copy and paste a formatted citation
Spandidos Publications style
Fu W, Sun C, Dai L, Yang L and Zhang Y: Relationship between COPD and polymorphisms of HOX-1 and mEPH in a Chinese population. Oncol Rep 17: 483-488, 2007.
APA
Fu, W., Sun, C., Dai, L., Yang, L., & Zhang, Y. (2007). Relationship between COPD and polymorphisms of HOX-1 and mEPH in a Chinese population. Oncology Reports, 17, 483-488. https://doi.org/10.3892/or.17.2.483
MLA
Fu, W., Sun, C., Dai, L., Yang, L., Zhang, Y."Relationship between COPD and polymorphisms of HOX-1 and mEPH in a Chinese population". Oncology Reports 17.2 (2007): 483-488.
Chicago
Fu, W., Sun, C., Dai, L., Yang, L., Zhang, Y."Relationship between COPD and polymorphisms of HOX-1 and mEPH in a Chinese population". Oncology Reports 17, no. 2 (2007): 483-488. https://doi.org/10.3892/or.17.2.483
Copy and paste a formatted citation
x
Spandidos Publications style
Fu W, Sun C, Dai L, Yang L and Zhang Y: Relationship between COPD and polymorphisms of HOX-1 and mEPH in a Chinese population. Oncol Rep 17: 483-488, 2007.
APA
Fu, W., Sun, C., Dai, L., Yang, L., & Zhang, Y. (2007). Relationship between COPD and polymorphisms of HOX-1 and mEPH in a Chinese population. Oncology Reports, 17, 483-488. https://doi.org/10.3892/or.17.2.483
MLA
Fu, W., Sun, C., Dai, L., Yang, L., Zhang, Y."Relationship between COPD and polymorphisms of HOX-1 and mEPH in a Chinese population". Oncology Reports 17.2 (2007): 483-488.
Chicago
Fu, W., Sun, C., Dai, L., Yang, L., Zhang, Y."Relationship between COPD and polymorphisms of HOX-1 and mEPH in a Chinese population". Oncology Reports 17, no. 2 (2007): 483-488. https://doi.org/10.3892/or.17.2.483
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