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Increased BRCA1 protein in mammary tumours of rats fed marine ω-3 fatty acids

  • Authors:
    • Marie-Lise Jourdan
    • Karine Mahéo
    • Aurélia Barascu
    • Caroline Goupille
    • Monique Peffault De Latour
    • Philippe Bougnoux
    • Pascale G. Rio

  • View Affiliations

  • Published online on: April 1, 2007     https://doi.org/10.3892/or.17.4.713
  • Pages: 713-719
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Abstract

Any factor affecting BRCA gene regulation may be of interest in the prevention of breast tumourigenesis. We studied the influence of dietary docosahexaenoic acid (DHA), a major ω-3 fatty acid present in marine products, on rat autochthonous mammary tumourigenesis. DHA-supplementation significantly reduced the incidence of tumours (30%, P=0.007) and led to a 60% increase (P=0.02) in BRCA1 protein level. Since DHA influences the product of a major tumour suppressor gene, this finding may contribute to the observation that high-fish consumption reduces the risk of breast cancer.

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Journal Cover

April 2007
Volume 17 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Journal Metrics
  • Impact Factor: 4.2
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 8.4
  • CiteScore Rank: Q1: #68/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.786
  • SCImago Journal Rank (SJR): 0.812
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Spandidos Publications style
Jourdan M, Mahéo K, Barascu A, Goupille C, De Latour MP, Bougnoux P and Rio PG: Increased BRCA1 protein in mammary tumours of rats fed marine ω-3 fatty acids. Oncol Rep 17: 713-719, 2007
APA
Jourdan, M., Mahéo, K., Barascu, A., Goupille, C., De Latour, M.P., Bougnoux, P., & Rio, P.G. (2007). Increased BRCA1 protein in mammary tumours of rats fed marine ω-3 fatty acids. Oncology Reports, 17, 713-719. https://doi.org/10.3892/or.17.4.713
MLA
Jourdan, M., Mahéo, K., Barascu, A., Goupille, C., De Latour, M. P., Bougnoux, P., Rio, P. G."Increased BRCA1 protein in mammary tumours of rats fed marine ω-3 fatty acids". Oncology Reports 17.4 (2007): 713-719.
Chicago
Jourdan, M., Mahéo, K., Barascu, A., Goupille, C., De Latour, M. P., Bougnoux, P., Rio, P. G."Increased BRCA1 protein in mammary tumours of rats fed marine ω-3 fatty acids". Oncology Reports 17, no. 4 (2007): 713-719. https://doi.org/10.3892/or.17.4.713