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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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April 2007 Volume 17 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Association of extracellular matrix metalloproteinase inducer in endometrial carcinoma with patient outcomes and clinicopathogenesis using monoclonal antibody 12C3

  • Authors:
    • Kazu Ueda
    • Kyosuke Yamada
    • Mitsuyoshi Urashima
    • Yoshio Ishibashi
    • Misako Shirai
    • Takashi Nikaido
    • Hiroyuki Takahashi
    • Aikou Okamoto
    • Misato Saito
    • Makoto Yasuda
    • Kiyoshi Ohkawa
    • Tadao Tanaka

  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Jikei University School of Medicine, Minato-ku, Tokyo 105-8461, Japan
  • Pages: 731-735
    |
    Published online on: April 1, 2007
       https://doi.org/10.3892/or.17.4.731
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Abstract

Extracellular matrix metalloproteinase inducer (EMMPRIN) is a member of the immunoglobulin superfamily of adhesion molecules and has a role in the activation of several matrix metalloproteinases (MMPs). We evaluated whether EMMPRIN expression is related to tumor progression and patient outcome in human endometrial carcinoma. Paraffin-embedded surgical tissue samples from 112 patients with endometrial carcinoma were stained with anti-EMMPRIN antibody (monoclonal antibody 12C3:MoAb 12C3) for immunohistochemical analysis. EMMPRIN protein was expressed in cancerous lesions with the incidence of 97.3% (109 of 112 cases), but not in normal lesions. The scores determined by the combination of intensity and pattern of EMMPRIN staining in cancer cells correlated significantly with various histopathological risk factors: advanced stage, P=0.001; poorly differentiated carcinoma, P<0.001; lymph node metastasis, P=0.002; and lymphatic vessel infiltration, P=0.027. More importantly, recurrence-free survival was shortened in patients with higher EMMPRIN scores (HR, 3.08; 95% CI, 1.32-7.19; P=0.01). These results suggest that measurement of EMMPRIN expression with simple immunohistochemical staining may enhance the understanding of the pathophysiology of endometrial carcinoma.

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Copy and paste a formatted citation
Spandidos Publications style
Ueda K, Yamada K, Urashima M, Ishibashi Y, Shirai M, Nikaido T, Takahashi H, Okamoto A, Saito M, Yasuda M, Yasuda M, et al: Association of extracellular matrix metalloproteinase inducer in endometrial carcinoma with patient outcomes and clinicopathogenesis using monoclonal antibody 12C3. Oncol Rep 17: 731-735, 2007.
APA
Ueda, K., Yamada, K., Urashima, M., Ishibashi, Y., Shirai, M., Nikaido, T. ... Tanaka, T. (2007). Association of extracellular matrix metalloproteinase inducer in endometrial carcinoma with patient outcomes and clinicopathogenesis using monoclonal antibody 12C3. Oncology Reports, 17, 731-735. https://doi.org/10.3892/or.17.4.731
MLA
Ueda, K., Yamada, K., Urashima, M., Ishibashi, Y., Shirai, M., Nikaido, T., Takahashi, H., Okamoto, A., Saito, M., Yasuda, M., Ohkawa, K., Tanaka, T."Association of extracellular matrix metalloproteinase inducer in endometrial carcinoma with patient outcomes and clinicopathogenesis using monoclonal antibody 12C3". Oncology Reports 17.4 (2007): 731-735.
Chicago
Ueda, K., Yamada, K., Urashima, M., Ishibashi, Y., Shirai, M., Nikaido, T., Takahashi, H., Okamoto, A., Saito, M., Yasuda, M., Ohkawa, K., Tanaka, T."Association of extracellular matrix metalloproteinase inducer in endometrial carcinoma with patient outcomes and clinicopathogenesis using monoclonal antibody 12C3". Oncology Reports 17, no. 4 (2007): 731-735. https://doi.org/10.3892/or.17.4.731
Copy and paste a formatted citation
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Spandidos Publications style
Ueda K, Yamada K, Urashima M, Ishibashi Y, Shirai M, Nikaido T, Takahashi H, Okamoto A, Saito M, Yasuda M, Yasuda M, et al: Association of extracellular matrix metalloproteinase inducer in endometrial carcinoma with patient outcomes and clinicopathogenesis using monoclonal antibody 12C3. Oncol Rep 17: 731-735, 2007.
APA
Ueda, K., Yamada, K., Urashima, M., Ishibashi, Y., Shirai, M., Nikaido, T. ... Tanaka, T. (2007). Association of extracellular matrix metalloproteinase inducer in endometrial carcinoma with patient outcomes and clinicopathogenesis using monoclonal antibody 12C3. Oncology Reports, 17, 731-735. https://doi.org/10.3892/or.17.4.731
MLA
Ueda, K., Yamada, K., Urashima, M., Ishibashi, Y., Shirai, M., Nikaido, T., Takahashi, H., Okamoto, A., Saito, M., Yasuda, M., Ohkawa, K., Tanaka, T."Association of extracellular matrix metalloproteinase inducer in endometrial carcinoma with patient outcomes and clinicopathogenesis using monoclonal antibody 12C3". Oncology Reports 17.4 (2007): 731-735.
Chicago
Ueda, K., Yamada, K., Urashima, M., Ishibashi, Y., Shirai, M., Nikaido, T., Takahashi, H., Okamoto, A., Saito, M., Yasuda, M., Ohkawa, K., Tanaka, T."Association of extracellular matrix metalloproteinase inducer in endometrial carcinoma with patient outcomes and clinicopathogenesis using monoclonal antibody 12C3". Oncology Reports 17, no. 4 (2007): 731-735. https://doi.org/10.3892/or.17.4.731
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