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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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April 2007 Volume 17 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

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Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

KL-6 mucin is a useful immunohistochemical marker for cholangiocarcinoma

  • Authors:
    • Wei Tang
    • Qian Guo
    • Xianjun Qu
    • Yoshinori Inagaki
    • Yasuji Seyama
    • Yutaka Midorikawa
    • Ruoyan Gai
    • Norihiro Kokudo
    • Yasuhiko Sugawara
    • Munehiro Nakata
    • Masatoshi Makuuchi

  • View Affiliations / Copyright

    Affiliations: Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan. tang-sur@h.u-tokyo.ac.jp
  • Pages: 737-741
    |
    Published online on: April 1, 2007
       https://doi.org/10.3892/or.17.4.737
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Abstract

This study aimed to clarify the clinical significance of the expression of KL-6 mucin, a type of MUC1, in primary liver cancer. Tissue specimens were collected from 21 patients with cholangiocarcinoma (CC), 78 with hepatocellular carcinoma (HCC), and 12 with combined hepatocellular and cholangiocarcinoma (cHCC-CC). Immunohistochemical analysis was done using a monoclonal antibody for KL-6 mucin as well as antibodies for Hep1 or CK7. KL-6 staining was positive in all the CC tissues examined, while it was not positive in any of the HCC tissues. Similar selectivity of KL-6 staining was also observed in the cHCC-CC specimens, and the cholangiocellular tissue could be clearly delineated by KL-6 staining. In contrast, 79.5% of HCC specimens and 25.0% of cHCC-CC specimens were positive for Hep1 in the hepatocellular tissues, while none of the CC or cHCC-CC specimens were positive in the cholangiocellular tissues. Staining for CK7 was positive in 95.2% of CC and 35.9% of HCC specimens, while 58.3 and 25.0% of cHCC-CC specimens displayed positivity for CK7 in the cholangiocellular and hepatocellular tissues, respectively. These results suggest that KL-6 may be a useful tumor marker for distinguishing CC from HCC. In addition, the high selectivity of KL-6 for cholangiocallular tissue may help to provide information for deciding the clinical strategy in cHCC-CC patients.

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Copy and paste a formatted citation
Spandidos Publications style
Tang W, Guo Q, Qu X, Inagaki Y, Seyama Y, Midorikawa Y, Gai R, Kokudo N, Sugawara Y, Nakata M, Nakata M, et al: KL-6 mucin is a useful immunohistochemical marker for cholangiocarcinoma. Oncol Rep 17: 737-741, 2007.
APA
Tang, W., Guo, Q., Qu, X., Inagaki, Y., Seyama, Y., Midorikawa, Y. ... Makuuchi, M. (2007). KL-6 mucin is a useful immunohistochemical marker for cholangiocarcinoma. Oncology Reports, 17, 737-741. https://doi.org/10.3892/or.17.4.737
MLA
Tang, W., Guo, Q., Qu, X., Inagaki, Y., Seyama, Y., Midorikawa, Y., Gai, R., Kokudo, N., Sugawara, Y., Nakata, M., Makuuchi, M."KL-6 mucin is a useful immunohistochemical marker for cholangiocarcinoma". Oncology Reports 17.4 (2007): 737-741.
Chicago
Tang, W., Guo, Q., Qu, X., Inagaki, Y., Seyama, Y., Midorikawa, Y., Gai, R., Kokudo, N., Sugawara, Y., Nakata, M., Makuuchi, M."KL-6 mucin is a useful immunohistochemical marker for cholangiocarcinoma". Oncology Reports 17, no. 4 (2007): 737-741. https://doi.org/10.3892/or.17.4.737
Copy and paste a formatted citation
x
Spandidos Publications style
Tang W, Guo Q, Qu X, Inagaki Y, Seyama Y, Midorikawa Y, Gai R, Kokudo N, Sugawara Y, Nakata M, Nakata M, et al: KL-6 mucin is a useful immunohistochemical marker for cholangiocarcinoma. Oncol Rep 17: 737-741, 2007.
APA
Tang, W., Guo, Q., Qu, X., Inagaki, Y., Seyama, Y., Midorikawa, Y. ... Makuuchi, M. (2007). KL-6 mucin is a useful immunohistochemical marker for cholangiocarcinoma. Oncology Reports, 17, 737-741. https://doi.org/10.3892/or.17.4.737
MLA
Tang, W., Guo, Q., Qu, X., Inagaki, Y., Seyama, Y., Midorikawa, Y., Gai, R., Kokudo, N., Sugawara, Y., Nakata, M., Makuuchi, M."KL-6 mucin is a useful immunohistochemical marker for cholangiocarcinoma". Oncology Reports 17.4 (2007): 737-741.
Chicago
Tang, W., Guo, Q., Qu, X., Inagaki, Y., Seyama, Y., Midorikawa, Y., Gai, R., Kokudo, N., Sugawara, Y., Nakata, M., Makuuchi, M."KL-6 mucin is a useful immunohistochemical marker for cholangiocarcinoma". Oncology Reports 17, no. 4 (2007): 737-741. https://doi.org/10.3892/or.17.4.737
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