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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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April 2007 Volume 17 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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April 2007 Volume 17 Issue 4

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Article

Significance of glutathione S-transferases M1, T1 and P1 polymorphisms in Swedish melanoma patients

  • Authors:
    • H. Bu
    • I. Rosdahl
    • K. Holmdahl-Källen
    • X-F. Sun
    • H. Zhang

  • View Affiliations / Copyright

    Affiliations: Division of Dermatology, Department of Biomedicine and Surgery, Linköping University, SE-581 85 Linköping, Sweden
  • Pages: 859-864
    |
    Published online on: April 1, 2007
       https://doi.org/10.3892/or.17.4.859
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Abstract

Polymorphisms of GSTM1, GSTT1 and GSTP1 were examined in melanoma patients and tumor-free individuals. Relationships between the polymorphisms and tumor characteristics and pigment phenotypes of the patients were analyzed. There was no significant difference in GSTM1 null and GSTT1 null genotypes nor GSTP1 GG genotype between melanoma patients and controls. In melanoma patients, these polymorphisms were not correlated with early or later onset of melanomas or gender of the patients. Frequency of GSTM1 null genotype was higher in patients with melanoma >2.5 mm than in those with tumors <1.0 mm, and higher frequency was found in nodular melanoma than in the other tumor types. GSTP1 GG genotype was more often found in the patients with brown and mixed eye color or brown and black hair than those with blue and green eyes or blond hair. It is unlikely that polymorphisms of GSTM1, GSTT1 and GSTP1 are general risk factors for melanoma in the Swedish population. GSTM1 null genotype was correlated with Breslow thickness and tumor type, which might serve as an additional biomarker for a rapid tumor progression. GSTP1 GG increases risk for melanoma in the subgroup of individuals with dark eyes or hair.

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Copy and paste a formatted citation
Spandidos Publications style
Bu H, Rosdahl I, Holmdahl-Källen K, Sun X and Zhang H: Significance of glutathione S-transferases M1, T1 and P1 polymorphisms in Swedish melanoma patients. Oncol Rep 17: 859-864, 2007.
APA
Bu, H., Rosdahl, I., Holmdahl-Källen, K., Sun, X., & Zhang, H. (2007). Significance of glutathione S-transferases M1, T1 and P1 polymorphisms in Swedish melanoma patients. Oncology Reports, 17, 859-864. https://doi.org/10.3892/or.17.4.859
MLA
Bu, H., Rosdahl, I., Holmdahl-Källen, K., Sun, X., Zhang, H."Significance of glutathione S-transferases M1, T1 and P1 polymorphisms in Swedish melanoma patients". Oncology Reports 17.4 (2007): 859-864.
Chicago
Bu, H., Rosdahl, I., Holmdahl-Källen, K., Sun, X., Zhang, H."Significance of glutathione S-transferases M1, T1 and P1 polymorphisms in Swedish melanoma patients". Oncology Reports 17, no. 4 (2007): 859-864. https://doi.org/10.3892/or.17.4.859
Copy and paste a formatted citation
x
Spandidos Publications style
Bu H, Rosdahl I, Holmdahl-Källen K, Sun X and Zhang H: Significance of glutathione S-transferases M1, T1 and P1 polymorphisms in Swedish melanoma patients. Oncol Rep 17: 859-864, 2007.
APA
Bu, H., Rosdahl, I., Holmdahl-Källen, K., Sun, X., & Zhang, H. (2007). Significance of glutathione S-transferases M1, T1 and P1 polymorphisms in Swedish melanoma patients. Oncology Reports, 17, 859-864. https://doi.org/10.3892/or.17.4.859
MLA
Bu, H., Rosdahl, I., Holmdahl-Källen, K., Sun, X., Zhang, H."Significance of glutathione S-transferases M1, T1 and P1 polymorphisms in Swedish melanoma patients". Oncology Reports 17.4 (2007): 859-864.
Chicago
Bu, H., Rosdahl, I., Holmdahl-Källen, K., Sun, X., Zhang, H."Significance of glutathione S-transferases M1, T1 and P1 polymorphisms in Swedish melanoma patients". Oncology Reports 17, no. 4 (2007): 859-864. https://doi.org/10.3892/or.17.4.859
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