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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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June 2007 Volume 17 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

GADD34 induces p21 expression and cellular senescence

  • Authors:
    • Kahori Minami
    • Hirokazu Inoue
    • Takao Terashita
    • Takahiro Kawakami
    • Ryosuke Watanabe
    • Masataka Haneda
    • Ken-Ichi Isobe
    • Hidetoshi Okabe
    • Tokuhiro Chano

  • View Affiliations

    Affiliations: Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Shiga 520-2192, Japan
  • Published online on: June 1, 2007     https://doi.org/10.3892/or.17.6.1481
  • Pages: 1481-1485
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Abstract

We previously identified GADD34 (growth arrest and DNA damage protein 34) by screening for genes involved in oncogenic-transformation and/or cellular senescence in Ras-transformed rat F2408 fibroblasts (7EJ-Ras), which exhibit anchorage-independent growth and do not senesce. In the current study, we found that transduction of 7EJ-Ras cells with a retroviral vector expressing GADD34 suppressed their proliferation. Furthermore, we observed that fibroblasts derived from GADD34-knockout mice (GADD34-KO MEFs) did not undergo senescence. Whereas the expression of p21 was decreased in GADD34 KO MEFs, its expression was rescued in these cells by ectopic expression of GADD34 by retroviral transduction. These findings suggest that GADD34 contributes to the regulation of p21 expression, and that it suppresses cellular proliferation through the induction of cellular senescence.

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Copy and paste a formatted citation
Spandidos Publications style
Minami K, Inoue H, Terashita T, Kawakami T, Watanabe R, Haneda M, Isobe K, Okabe H and Chano T: GADD34 induces p21 expression and cellular senescence. Oncol Rep 17: 1481-1485, 2007.
APA
Minami, K., Inoue, H., Terashita, T., Kawakami, T., Watanabe, R., Haneda, M. ... Chano, T. (2007). GADD34 induces p21 expression and cellular senescence. Oncology Reports, 17, 1481-1485. https://doi.org/10.3892/or.17.6.1481
MLA
Minami, K., Inoue, H., Terashita, T., Kawakami, T., Watanabe, R., Haneda, M., Isobe, K., Okabe, H., Chano, T."GADD34 induces p21 expression and cellular senescence". Oncology Reports 17.6 (2007): 1481-1485.
Chicago
Minami, K., Inoue, H., Terashita, T., Kawakami, T., Watanabe, R., Haneda, M., Isobe, K., Okabe, H., Chano, T."GADD34 induces p21 expression and cellular senescence". Oncology Reports 17, no. 6 (2007): 1481-1485. https://doi.org/10.3892/or.17.6.1481
Copy and paste a formatted citation
x
Spandidos Publications style
Minami K, Inoue H, Terashita T, Kawakami T, Watanabe R, Haneda M, Isobe K, Okabe H and Chano T: GADD34 induces p21 expression and cellular senescence. Oncol Rep 17: 1481-1485, 2007.
APA
Minami, K., Inoue, H., Terashita, T., Kawakami, T., Watanabe, R., Haneda, M. ... Chano, T. (2007). GADD34 induces p21 expression and cellular senescence. Oncology Reports, 17, 1481-1485. https://doi.org/10.3892/or.17.6.1481
MLA
Minami, K., Inoue, H., Terashita, T., Kawakami, T., Watanabe, R., Haneda, M., Isobe, K., Okabe, H., Chano, T."GADD34 induces p21 expression and cellular senescence". Oncology Reports 17.6 (2007): 1481-1485.
Chicago
Minami, K., Inoue, H., Terashita, T., Kawakami, T., Watanabe, R., Haneda, M., Isobe, K., Okabe, H., Chano, T."GADD34 induces p21 expression and cellular senescence". Oncology Reports 17, no. 6 (2007): 1481-1485. https://doi.org/10.3892/or.17.6.1481
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