8-Nitroguanine as a potential biomarker for progression of malignant fibrous histiocytoma, a model of inflammation-related cancer

  • Authors:
    • Yoko Hoki
    • Mariko Murata
    • Yusuke Hiraku
    • Ning Ma
    • Akihiko Matsumine
    • Atsumasa Uchida
    • Shosuke Kawanishi
  • View Affiliations

  • Published online on: November 1, 2007     https://doi.org/10.3892/or.18.5.1165
  • Pages: 1165-1169
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Abstract

Chronic inflammation is a critical component of carcinogenesis and tumor progression. Reactive nitrogen and oxygen species generated by inflammatory cells form mutagenic DNA lesions, such as 8-nitroguanine, which may play an integral role in inflammation-related carcinogenesis. Hypoxia-inducible factor (HIF)-1α has been established as a prognostic biomarker in various tumors, including malignant fibrous histiocytoma (MFH). The aim of this study was to evaluate the impact of 8-nitroguanine formation and HIF-1α expression on the prognosis of patients with inflammation-related cancer. Immunohistochemical analyses were employed to examine the distribution of 8-nitroguanine and HIF-1α, using clinical specimens from 36 patients with MFH as a model of inflammation-related cancer. 8-Nitroguanine formation was predominately observed in the nuclei of tumor cells and inflammatory cells in tumor tissues, while HIF-1α was expressed in the cytoplasm and nuclei of tumor cells. Little or no immunoreactivity of 8-nitroguanine and HIF-1α was observed in adjacent non-tumor tissues. Significantly higher levels of both 8-nitroguanine and HIF-1α were observed in the tissue specimens of deceased patients than in those of living subjects. Survival curves analyzed by the Kaplan-Meier method differed significantly between the high- and low-staining groups of 8-nitroguanine (p=0.00003) as well as HIF-1α (p=0.01104). These results suggest a significant role of the pathway of iNOS-dependent 8-nitroguanine formation via HIF-1α and NF-κB on the progression of inflammation-related cancer. In conclusion, 8-nitroguanine is an excellent candidate prognostic and predictive biomarker together with HIF-1α in inflammation-related tumor progression.

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November 2007
Volume 18 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Hoki Y, Murata M, Hiraku Y, Ma N, Matsumine A, Uchida A and Kawanishi S: 8-Nitroguanine as a potential biomarker for progression of malignant fibrous histiocytoma, a model of inflammation-related cancer. Oncol Rep 18: 1165-1169, 2007
APA
Hoki, Y., Murata, M., Hiraku, Y., Ma, N., Matsumine, A., Uchida, A., & Kawanishi, S. (2007). 8-Nitroguanine as a potential biomarker for progression of malignant fibrous histiocytoma, a model of inflammation-related cancer. Oncology Reports, 18, 1165-1169. https://doi.org/10.3892/or.18.5.1165
MLA
Hoki, Y., Murata, M., Hiraku, Y., Ma, N., Matsumine, A., Uchida, A., Kawanishi, S."8-Nitroguanine as a potential biomarker for progression of malignant fibrous histiocytoma, a model of inflammation-related cancer". Oncology Reports 18.5 (2007): 1165-1169.
Chicago
Hoki, Y., Murata, M., Hiraku, Y., Ma, N., Matsumine, A., Uchida, A., Kawanishi, S."8-Nitroguanine as a potential biomarker for progression of malignant fibrous histiocytoma, a model of inflammation-related cancer". Oncology Reports 18, no. 5 (2007): 1165-1169. https://doi.org/10.3892/or.18.5.1165