c-Jun, a crucial molecule in metastasis of breast cancer and potential target for biotherapy

  • Authors:
    • Yan Zhang
    • Xiaoyun Pu
    • Ming Shi
    • Liyong Chen
    • Lu Qian
    • Yuhua Song
    • Guogang Yuan
    • Hao Zhang
    • Ming Yu
    • Meiru Hu
    • Beifen Shen
    • Ning Guo
  • View Affiliations

  • Published online on: November 1, 2007     https://doi.org/10.3892/or.18.5.1207
  • Pages: 1207-1212
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Abstract

Human breast cancer cell line SKBR3 expresses high level of the ErbB2 molecule, which has been associated with poor prognosis of breast cancer. Elevated ErbB2 functions as a transactivating co-receptor and promotes the formation of ErbB2 containing heterodimers, which are more mitogenic and transforming, and have a higher ligand affinity and signaling potency by virtue of the potent latent kinase activity of ErbB2. Interestingly, SKBR3 cells are non-tumorigenic in nude mice. By ectopic overexpression of c-Jun in SKBR3 cells, involvement of c-Jun in invasiveness and metastasis in vivo was investigated in this study. The critical role of c-Jun in the tumorigenesis and metastasis is demonstrated in nude mice.

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November 2007
Volume 18 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Zhang Y, Pu X, Shi M, Chen L, Qian L, Song Y, Yuan G, Zhang H, Yu M, Hu M, Hu M, et al: c-Jun, a crucial molecule in metastasis of breast cancer and potential target for biotherapy. Oncol Rep 18: 1207-1212, 2007.
APA
Zhang, Y., Pu, X., Shi, M., Chen, L., Qian, L., Song, Y. ... Guo, N. (2007). c-Jun, a crucial molecule in metastasis of breast cancer and potential target for biotherapy. Oncology Reports, 18, 1207-1212. https://doi.org/10.3892/or.18.5.1207
MLA
Zhang, Y., Pu, X., Shi, M., Chen, L., Qian, L., Song, Y., Yuan, G., Zhang, H., Yu, M., Hu, M., Shen, B., Guo, N."c-Jun, a crucial molecule in metastasis of breast cancer and potential target for biotherapy". Oncology Reports 18.5 (2007): 1207-1212.
Chicago
Zhang, Y., Pu, X., Shi, M., Chen, L., Qian, L., Song, Y., Yuan, G., Zhang, H., Yu, M., Hu, M., Shen, B., Guo, N."c-Jun, a crucial molecule in metastasis of breast cancer and potential target for biotherapy". Oncology Reports 18, no. 5 (2007): 1207-1212. https://doi.org/10.3892/or.18.5.1207